IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-42960-6.html
   My bibliography  Save this article

Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics

Author

Listed:
  • Young Min Park

    (University of Southern California
    Yonsei University College of Medicine)

  • De-Chen Lin

    (University of Southern California)

Abstract

Spatial transcriptomic profiling of cancer has enabled spatial delineation of malignant transcriptional heterogeneity, intercellular communication, and organization of microanatomical structures within the tumor microenvironment. This technical breakthrough paves the way for the development of precision diagnostic methods and targeted therapies.

Suggested Citation

  • Young Min Park & De-Chen Lin, 2023. "Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42960-6
    DOI: 10.1038/s41467-023-42960-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-42960-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-42960-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jingjing Qi & Hongxiang Sun & Yao Zhang & Zhengting Wang & Zhenzhen Xun & Ziyi Li & Xinyu Ding & Rujuan Bao & Liwen Hong & Wenqing Jia & Fei Fang & Hongzhi Liu & Lei Chen & Jie Zhong & Duowu Zou & Lia, 2022. "Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Artem Lomakin & Jessica Svedlund & Carina Strell & Milana Gataric & Artem Shmatko & Gleb Rukhovich & Jun Sung Park & Young Seok Ju & Stefan Dentro & Vitalii Kleshchevnikov & Vasyl Vaskivskyi & Tong Li, 2022. "Spatial genomics maps the structure, nature and evolution of cancer clones," Nature, Nature, vol. 611(7936), pages 594-602, November.
    3. Rohit Arora & Christian Cao & Mehul Kumar & Sarthak Sinha & Ayan Chanda & Reid McNeil & Divya Samuel & Rahul K. Arora & T. Wayne Matthews & Shamir Chandarana & Robert Hart & Joseph C. Dort & Jeff Bier, 2023. "Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kaichen Xu & Yan Lu & Suyang Hou & Kainan Liu & Yihang Du & Mengqian Huang & Hao Feng & Hao Wu & Xiaobo Sun, 2024. "Detecting anomalous anatomic regions in spatial transcriptomics with STANDS," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Zhenlin Yang & He Tian & Xiaowei Chen & Bozhao Li & Guangyu Bai & Qingyuan Cai & Jiachen Xu & Wei Guo & Shuaibo Wang & Yue Peng & Qing Liang & Liyan Xue & Shugeng Gao, 2024. "Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Chuanyuan Wei & Wei Sun & Kangjie Shen & Jingqin Zhong & Wanlin Liu & Zixu Gao & Yu Xu & Lu Wang & Tu Hu & Ming Ren & Yinlam Li & Yu Zhu & Shaoluan Zheng & Ming Zhu & Rongkui Luo & Yanwen Yang & Yingy, 2023. "Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Z. L. Liu & X. Y. Meng & R. J. Bao & M. Y. Shen & J. J. Sun & W. D. Chen & F. Liu & Y. He, 2024. "Single cell deciphering of progression trajectories of the tumor ecosystem in head and neck cancer," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Victoria Stary & Ram V. Pandey & Julia List & Lisa Kleissl & Florian Deckert & Julijan Kabiljo & Johannes Laengle & Vasileios Gerakopoulos & Rudolf Oehler & Lukas Watzke & Matthias Farlik & Samuel W. , 2024. "Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Marija Pizurica & Yuanning Zheng & Francisco Carrillo-Perez & Humaira Noor & Wei Yao & Christian Wohlfart & Antoaneta Vladimirova & Kathleen Marchal & Olivier Gevaert, 2024. "Digital profiling of gene expression from histology images with linearized attention," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    7. Han-Ying Huang & Yan-Zhou Chen & Chuang Zhao & Xin-Nan Zheng & Kai Yu & Jia-Xing Yue & Huai-Qiang Ju & Yan-Xia Shi & Lin Tian, 2024. "Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    8. Zhixing Zhong & Junchen Hou & Zhixian Yao & Lei Dong & Feng Liu & Junqiu Yue & Tiantian Wu & Junhua Zheng & Gaoliang Ouyang & Chaoyong Yang & Jia Song, 2024. "Domain generalization enables general cancer cell annotation in single-cell and spatial transcriptomics," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    9. Hugo Croizer & Rana Mhaidly & Yann Kieffer & Geraldine Gentric & Lounes Djerroudi & Renaud Leclere & Floriane Pelon & Catherine Robley & Mylene Bohec & Arnaud Meng & Didier Meseure & Emanuela Romano &, 2024. "Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-28, December.
    10. Weiyuan Li & Lu Pan & Weifeng Hong & Florent Ginhoux & Xuan Zhang & Chunjie Xiao & Xuexin Li, 2024. "A single-cell pan-cancer analysis to show the variability of tumor-infiltrating myeloid cells in immune checkpoint blockade," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    11. Marina T. Broz & Emily Y. Ko & Kristin Ishaya & Jinfen Xiao & Marco Simone & Xen Ping Hoi & Roberta Piras & Basia Gala & Fernando H. G. Tessaro & Anja Karlstaedt & Sandra Orsulic & Amanda W. Lund & Ke, 2024. "Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    12. Ning Li & Qin Zhu & Yuhua Tian & Kyung Jin Ahn & Xin Wang & Zvi Cramer & Justine Jou & Ian W. Folkert & Pengfei Yu & Stephanie Adams-Tzivelekidis & Priyanka Sehgal & Najia N. Mahmoud & Cary B. Aarons , 2023. "Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    13. Shimrit Mayer & Tomer Milo & Achinoam Isaacson & Coral Halperin & Shoval Miyara & Yaniv Stein & Chen Lior & Meirav Pevsner-Fischer & Eldad Tzahor & Avi Mayo & Uri Alon & Ruth Scherz-Shouval, 2023. "The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    14. Lies van Baarle & Veronica De Simone & Linda Schneider & Sneha Santhosh & Saeed Abdurahiman & Francesca Biscu & Reiner Schneider & Lisa Zanoletti & Renata Siqueira de Mello & Sara Verbandt & Zedong Hu, 2024. "IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42960-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.