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Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics

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  • Young Min Park

    (University of Southern California
    Yonsei University College of Medicine)

  • De-Chen Lin

    (University of Southern California)

Abstract

Spatial transcriptomic profiling of cancer has enabled spatial delineation of malignant transcriptional heterogeneity, intercellular communication, and organization of microanatomical structures within the tumor microenvironment. This technical breakthrough paves the way for the development of precision diagnostic methods and targeted therapies.

Suggested Citation

  • Young Min Park & De-Chen Lin, 2023. "Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42960-6
    DOI: 10.1038/s41467-023-42960-6
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    1. Jingjing Qi & Hongxiang Sun & Yao Zhang & Zhengting Wang & Zhenzhen Xun & Ziyi Li & Xinyu Ding & Rujuan Bao & Liwen Hong & Wenqing Jia & Fei Fang & Hongzhi Liu & Lei Chen & Jie Zhong & Duowu Zou & Lia, 2022. "Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Artem Lomakin & Jessica Svedlund & Carina Strell & Milana Gataric & Artem Shmatko & Gleb Rukhovich & Jun Sung Park & Young Seok Ju & Stefan Dentro & Vitalii Kleshchevnikov & Vasyl Vaskivskyi & Tong Li, 2022. "Spatial genomics maps the structure, nature and evolution of cancer clones," Nature, Nature, vol. 611(7936), pages 594-602, November.
    3. Rohit Arora & Christian Cao & Mehul Kumar & Sarthak Sinha & Ayan Chanda & Reid McNeil & Divya Samuel & Rahul K. Arora & T. Wayne Matthews & Shamir Chandarana & Robert Hart & Joseph C. Dort & Jeff Bier, 2023. "Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
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