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Low mutation rate in epaulette sharks is consistent with a slow rate of evolution in sharks

Author

Listed:
  • Ashley T. Sendell-Price

    (Uppsala University
    University of Warwick)

  • Frank J. Tulenko

    (Monash University)

  • Mats Pettersson

    (Uppsala University)

  • Du Kang

    (Texas State University)

  • Margo Montandon

    (Monash University)

  • Sylke Winkler

    (Max-Planck Institute of Molecular Cell Biology and Genetics)

  • Kathleen Kulb

    (Max-Planck Institute of Molecular Cell Biology and Genetics)

  • Gavin P. Naylor

    (University of Florida)

  • Adam Phillippy

    (National Human Genome Research Institute, National Institutes of Health Bethesda)

  • Olivier Fedrigo

    (Rockefeller University)

  • Jacquelyn Mountcastle

    (Duke University)

  • Jennifer R. Balacco

    (Duke University)

  • Amalia Dutra

    (National Institutes of Health Bethesda)

  • Rebecca E. Dale

    (Monash University)

  • Bettina Haase

    (Rockefeller University)

  • Erich D. Jarvis

    (Rockefeller University)

  • Gene Myers

    (Max-Planck Institute of Molecular Cell Biology and Genetics
    Center of Systems Biology Dresden)

  • Shawn M. Burgess

    (National Human Genome Research Institute, National Institutes of Health Bethesda)

  • Peter D. Currie

    (Monash University
    Monash University)

  • Leif Andersson

    (Uppsala University
    Texas A&M University)

  • Manfred Schartl

    (University of Würzburg)

Abstract

Sharks occupy diverse ecological niches and play critical roles in marine ecosystems, often acting as apex predators. They are considered a slow-evolving lineage and have been suggested to exhibit exceptionally low cancer rates. These two features could be explained by a low nuclear mutation rate. Here, we provide a direct estimate of the nuclear mutation rate in the epaulette shark (Hemiscyllium ocellatum). We generate a high-quality reference genome, and resequence the whole genomes of parents and nine offspring to detect de novo mutations. Using stringent criteria, we estimate a mutation rate of 7×10−10 per base pair, per generation. This represents one of the lowest directly estimated mutation rates for any vertebrate clade, indicating that this basal vertebrate group is indeed a slowly evolving lineage whose ability to restore genetic diversity following a sustained population bottleneck may be hampered by a low mutation rate.

Suggested Citation

  • Ashley T. Sendell-Price & Frank J. Tulenko & Mats Pettersson & Du Kang & Margo Montandon & Sylke Winkler & Kathleen Kulb & Gavin P. Naylor & Adam Phillippy & Olivier Fedrigo & Jacquelyn Mountcastle & , 2023. "Low mutation rate in epaulette sharks is consistent with a slow rate of evolution in sharks," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42238-x
    DOI: 10.1038/s41467-023-42238-x
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