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Dual hypoxia-responsive supramolecular complex for cancer target therapy

Author

Listed:
  • Jian-Shuang Guo

    (Nankai University)

  • Juan-Juan Li

    (Nankai University)

  • Ze-Han Wang

    (Nankai University)

  • Yang Liu

    (Nankai University)

  • Yu-Xin Yue

    (Nankai University)

  • Hua-Bin Li

    (Nankai University)

  • Xiu-He Zhao

    (Nankai University)

  • Yuan-Jun Sun

    (Nankai University)

  • Ya-Hui Ding

    (Nankai University)

  • Fei Ding

    (Nankai University)

  • Dong-Sheng Guo

    (Nankai University)

  • Liang Wang

    (Nankai University)

  • Yue Chen

    (Nankai University)

Abstract

The prognosis with pancreatic cancer is among the poorest of any human cancer. One of the important factors is the tumor hypoxia. Targeting tumor hypoxia is considered a desirable therapeutic option. However, it has not been translated into clinical success in the treatment of pancreatic cancer. With enhanced cytotoxicities against hypoxic pancreatic cancer cells, BE-43547A2 (BE) may serve as a promising template for hypoxia target strategy. Here, based on rational modification, a BE prodrug (NMP-BE) is encapsulated into sulfonated azocalix[5]arene (SAC5A) to generate a supramolecular dual hypoxia-responsive complex NMP-BE@SAC5A. Benefited from the selective load release within cancer cells, NMP-BE@SAC5A markedly suppresses tumor growth at low dose in pancreatic cancer cells xenograft murine model without developing systemic toxicity. This research presents a strategy for the modification of covalent compounds to achieve efficient delivery within tumors, a horizon for the realization of safe and reinforced hypoxia target therapy using a simple approach.

Suggested Citation

  • Jian-Shuang Guo & Juan-Juan Li & Ze-Han Wang & Yang Liu & Yu-Xin Yue & Hua-Bin Li & Xiu-He Zhao & Yuan-Jun Sun & Ya-Hui Ding & Fei Ding & Dong-Sheng Guo & Liang Wang & Yue Chen, 2023. "Dual hypoxia-responsive supramolecular complex for cancer target therapy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41388-2
    DOI: 10.1038/s41467-023-41388-2
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    References listed on IDEAS

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    1. Jia-Hong Tian & Xin-Yue Hu & Zong-Ying Hu & Han-Wen Tian & Juan-Juan Li & Yu-Chen Pan & Hua-Bin Li & Dong-Sheng Guo, 2022. "A facile way to construct sensor array library via supramolecular chemistry for discriminating complex systems," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
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