IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-41042-x.html
   My bibliography  Save this article

Impact of dietary interventions on pre-diabetic oral and gut microbiome, metabolites and cytokines

Author

Listed:
  • Saar Shoer

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

  • Smadar Shilo

    (The Weizmann Institute of Science
    The Weizmann Institute of Science
    National Center for Childhood Diabetes, Schneider Children’s Medical Center)

  • Anastasia Godneva

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

  • Orly Ben-Yacov

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

  • Michal Rein

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

  • Bat Chen Wolf

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

  • Maya Lotan-Pompan

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

  • Noam Bar

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

  • Ervin I. Weiss

    (Tel Aviv University
    The Hebrew University-Hadassah School of Dental Medicine)

  • Yael Houri-Haddad

    (The Hebrew University-Hadassah School of Dental Medicine)

  • Yitzhak Pilpel

    (The Weizmann Institute of Science)

  • Adina Weinberger

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

  • Eran Segal

    (The Weizmann Institute of Science
    The Weizmann Institute of Science)

Abstract

Diabetes and associated comorbidities are a global health threat on the rise. We conducted a six-month dietary intervention in pre-diabetic individuals (NCT03222791), to mitigate the hyperglycemia and enhance metabolic health. The current work explores early diabetes markers in the 200 individuals who completed the trial. We find 166 of 2,803 measured features, including oral and gut microbial species and pathways, serum metabolites and cytokines, show significant change in response to a personalized postprandial glucose-targeting diet or the standard of care Mediterranean diet. These changes include established markers of hyperglycemia as well as novel features that can now be investigated as potential therapeutic targets. Our results indicate the microbiome mediates the effect of diet on glycemic, metabolic and immune measurements, with gut microbiome compositional change explaining 12.25% of serum metabolites variance. Although the gut microbiome displays greater compositional changes compared to the oral microbiome, the oral microbiome demonstrates more changes at the genetic level, with trends dependent on environmental richness and species prevalence in the population. In conclusion, our study shows dietary interventions can affect the microbiome, cardiometabolic profile and immune response of the host, and that these factors are well associated with each other, and can be harnessed for new therapeutic modalities.

Suggested Citation

  • Saar Shoer & Smadar Shilo & Anastasia Godneva & Orly Ben-Yacov & Michal Rein & Bat Chen Wolf & Maya Lotan-Pompan & Noam Bar & Ervin I. Weiss & Yael Houri-Haddad & Yitzhak Pilpel & Adina Weinberger & E, 2023. "Impact of dietary interventions on pre-diabetic oral and gut microbiome, metabolites and cytokines," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41042-x
    DOI: 10.1038/s41467-023-41042-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-41042-x
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-41042-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sabina Leanti La Rosa & Maria Louise Leth & Leszek Michalak & Morten Ejby Hansen & Nicholas A. Pudlo & Robert Glowacki & Gabriel Pereira & Christopher T. Workman & Magnus Ø. Arntzen & Phillip B. Pope , 2019. "The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    2. Daphna Rothschild & Sigal Leviatan & Ariel Hanemann & Yossi Cohen & Omer Weissbrod & Eran Segal, 2022. "An atlas of robust microbiome associations with phenotypic traits based on large-scale cohorts from two continents," PLOS ONE, Public Library of Science, vol. 17(3), pages 1-20, March.
    3. Noam Bar & Tal Korem & Omer Weissbrod & David Zeevi & Daphna Rothschild & Sigal Leviatan & Noa Kosower & Maya Lotan-Pompan & Adina Weinberger & Caroline I. Roy & Cristina Menni & Alessia Visconti & Ma, 2020. "A reference map of potential determinants for the human serum metabolome," Nature, Nature, vol. 588(7836), pages 135-140, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alexandra M. Cheney & Stephanann M. Costello & Nicholas V. Pinkham & Annie Waldum & Susan C. Broadaway & Maria Cotrina-Vidal & Marc Mergy & Brian Tripet & Douglas J. Kominsky & Heather M. Grifka-Walk , 2023. "Gut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Petros Andrikopoulos & Judith Aron-Wisnewsky & Rima Chakaroun & Antonis Myridakis & Sofia K. Forslund & Trine Nielsen & Solia Adriouch & Bridget Holmes & Julien Chilloux & Sara Vieira-Silva & Gwen Fal, 2023. "Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Shaza B. Zaghlool & Anna Halama & Nisha Stephan & Valborg Gudmundsdottir & Vilmundur Gudnason & Lori L. Jennings & Manonanthini Thangam & Emma Ahlqvist & Rayaz A. Malik & Omar M. E. Albagha & Abdul Ba, 2022. "Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Koen F. Dekkers & Sergi Sayols-Baixeras & Gabriel Baldanzi & Christoph Nowak & Ulf Hammar & Diem Nguyen & Georgios Varotsis & Louise Brunkwall & Nynne Nielsen & Aron C. Eklund & Jacob Bak Holm & H. Bj, 2022. "An online atlas of human plasma metabolite signatures of gut microbiome composition," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Ayya Keshet & Eran Segal, 2024. "Identification of gut microbiome features associated with host metabolic health in a large population-based cohort," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Efrat Muller & Itamar Shiryan & Elhanan Borenstein, 2024. "Multi-omic integration of microbiome data for identifying disease-associated modules," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    7. Sigal Leviatan & Saar Shoer & Daphna Rothschild & Maria Gorodetski & Eran Segal, 2022. "An expanded reference map of the human gut microbiome reveals hundreds of previously unknown species," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Kui Deng & Jin-jian Xu & Luqi Shen & Hui Zhao & Wanglong Gou & Fengzhe Xu & Yuanqing Fu & Zengliang Jiang & Menglei Shuai & Bang-yan Li & Wei Hu & Ju-Sheng Zheng & Yu-ming Chen, 2023. "Comparison of fecal and blood metabolome reveals inconsistent associations of the gut microbiota with cardiometabolic diseases," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41042-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.