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Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease

Author

Listed:
  • Stephanie Langella

    (Harvard Medical School)

  • N. Gil Barksdale

    (Harvard Medical School)

  • Daniel Vasquez

    (Universidad de Antioquia)

  • David Aguillon

    (Universidad de Antioquia)

  • Yinghua Chen

    (Banner Alzheimer’s Institute)

  • Yi Su

    (Banner Alzheimer’s Institute)

  • Natalia Acosta-Baena

    (Universidad de Antioquia)

  • Juliana Acosta-Uribe

    (Universidad de Antioquia
    University of California Santa Barbara)

  • Ana Y. Baena

    (Universidad de Antioquia)

  • Gloria Garcia-Ospina

    (Universidad de Antioquia)

  • Margarita Giraldo-Chica

    (Universidad de Antioquia)

  • Victoria Tirado

    (Universidad de Antioquia)

  • Claudia Muñoz

    (Universidad de Antioquia)

  • Silvia Ríos-Romenets

    (Universidad de Antioquia)

  • Claudia Guzman-Martínez

    (Universidad de Antioquia)

  • Gabriel Oliveira

    (Harvard Medical School)

  • Hyun-Sik Yang

    (Harvard Medical School)

  • Clara Vila-Castelar

    (Harvard Medical School)

  • Jeremy J. Pruzin

    (Banner Alzheimer’s Institute)

  • Valentina Ghisays

    (Banner Alzheimer’s Institute)

  • Joseph F. Arboleda-Velasquez

    (Harvard Medical School)

  • Kenneth S. Kosik

    (University of California Santa Barbara)

  • Eric M. Reiman

    (Banner Alzheimer’s Institute)

  • Francisco Lopera

    (Universidad de Antioquia)

  • Yakeel T. Quiroz

    (Harvard Medical School
    Universidad de Antioquia)

Abstract

Autosomal dominant Alzheimer’s disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may influence cognitive trajectories. Although apolipoprotein E (APOE) genotype and educational attainment both influence dementia onset in sporadic AD, evidence for these effects in ADAD is limited. To investigate the effects of APOE and educational attainment on age-related cognitive trajectories in ADAD, we analyzed data from 675 Presenilin-1 E280A mutation carriers and 594 non-carriers. Here we show that age-related cognitive decline is accelerated in ADAD mutation carriers who also have an APOE e4 allele compared to those who do not and delayed in mutation carriers who also have an APOE e2 allele compared to those who do not. Educational attainment is protective and moderates the effect of APOE on cognition. Despite ADAD mutation carriers being genetically determined to develop dementia, age-related cognitive decline may be influenced by other genetic and environmental factors.

Suggested Citation

  • Stephanie Langella & N. Gil Barksdale & Daniel Vasquez & David Aguillon & Yinghua Chen & Yi Su & Natalia Acosta-Baena & Juliana Acosta-Uribe & Ana Y. Baena & Gloria Garcia-Ospina & Margarita Giraldo-C, 2023. "Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40775-z
    DOI: 10.1038/s41467-023-40775-z
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    References listed on IDEAS

    as
    1. Xiangfei Meng & Carl D’Arcy, 2012. "Education and Dementia in the Context of the Cognitive Reserve Hypothesis: A Systematic Review with Meta-Analyses and Qualitative Analyses," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-16, June.
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