IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-40775-z.html
   My bibliography  Save this article

Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease

Author

Listed:
  • Stephanie Langella

    (Harvard Medical School)

  • N. Gil Barksdale

    (Harvard Medical School)

  • Daniel Vasquez

    (Universidad de Antioquia)

  • David Aguillon

    (Universidad de Antioquia)

  • Yinghua Chen

    (Banner Alzheimer’s Institute)

  • Yi Su

    (Banner Alzheimer’s Institute)

  • Natalia Acosta-Baena

    (Universidad de Antioquia)

  • Juliana Acosta-Uribe

    (Universidad de Antioquia
    University of California Santa Barbara)

  • Ana Y. Baena

    (Universidad de Antioquia)

  • Gloria Garcia-Ospina

    (Universidad de Antioquia)

  • Margarita Giraldo-Chica

    (Universidad de Antioquia)

  • Victoria Tirado

    (Universidad de Antioquia)

  • Claudia Muñoz

    (Universidad de Antioquia)

  • Silvia Ríos-Romenets

    (Universidad de Antioquia)

  • Claudia Guzman-Martínez

    (Universidad de Antioquia)

  • Gabriel Oliveira

    (Harvard Medical School)

  • Hyun-Sik Yang

    (Harvard Medical School)

  • Clara Vila-Castelar

    (Harvard Medical School)

  • Jeremy J. Pruzin

    (Banner Alzheimer’s Institute)

  • Valentina Ghisays

    (Banner Alzheimer’s Institute)

  • Joseph F. Arboleda-Velasquez

    (Harvard Medical School)

  • Kenneth S. Kosik

    (University of California Santa Barbara)

  • Eric M. Reiman

    (Banner Alzheimer’s Institute)

  • Francisco Lopera

    (Universidad de Antioquia)

  • Yakeel T. Quiroz

    (Harvard Medical School
    Universidad de Antioquia)

Abstract

Autosomal dominant Alzheimer’s disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may influence cognitive trajectories. Although apolipoprotein E (APOE) genotype and educational attainment both influence dementia onset in sporadic AD, evidence for these effects in ADAD is limited. To investigate the effects of APOE and educational attainment on age-related cognitive trajectories in ADAD, we analyzed data from 675 Presenilin-1 E280A mutation carriers and 594 non-carriers. Here we show that age-related cognitive decline is accelerated in ADAD mutation carriers who also have an APOE e4 allele compared to those who do not and delayed in mutation carriers who also have an APOE e2 allele compared to those who do not. Educational attainment is protective and moderates the effect of APOE on cognition. Despite ADAD mutation carriers being genetically determined to develop dementia, age-related cognitive decline may be influenced by other genetic and environmental factors.

Suggested Citation

  • Stephanie Langella & N. Gil Barksdale & Daniel Vasquez & David Aguillon & Yinghua Chen & Yi Su & Natalia Acosta-Baena & Juliana Acosta-Uribe & Ana Y. Baena & Gloria Garcia-Ospina & Margarita Giraldo-C, 2023. "Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40775-z
    DOI: 10.1038/s41467-023-40775-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-40775-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-40775-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Xiangfei Meng & Carl D’Arcy, 2012. "Education and Dementia in the Context of the Cognitive Reserve Hypothesis: A Systematic Review with Meta-Analyses and Qualitative Analyses," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-16, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ewa Jarosz, 2023. "Does ageing make life simpler? The dynamics, covariates, and implications of complexity of time-use patterns in late adulthood," Quality & Quantity: International Journal of Methodology, Springer, vol. 57(5), pages 4153-4170, October.
    2. Amitabh Chandra & Courtney Coile & Corina Mommaerts, 2023. "What Can Economics Say about Alzheimer's Disease?," Journal of Economic Literature, American Economic Association, vol. 61(2), pages 428-470, June.
    3. Liu, Hui & Chopik, William J. & Shrout, M. Rosie & Wang, Juwen, 2024. "A national longitudinal dyadic analysis of spousal education and cognitive decline in the United States," Social Science & Medicine, Elsevier, vol. 343(C).
    4. Lior Rennert & Sharon X. Xie, 2022. "Cox regression model under dependent truncation," Biometrics, The International Biometric Society, vol. 78(2), pages 460-473, June.
    5. Harling, Guy & Kobayashi, Lindsay C. & Farrell, Meagan T. & Wagner, Ryan G. & Tollman, Stephen & Berkman, Lisa, 2020. "Social contact, social support, and cognitive health in a population-based study of middle-aged and older men and women in rural South Africa," Social Science & Medicine, Elsevier, vol. 260(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40775-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.