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Photoredox cobalt-catalyzed regio-, diastereo- and enantioselective propargylation of aldehydes via propargyl radicals

Author

Listed:
  • Lei Wang

    (University of Chinese Academy of Sciences)

  • Chuiyi Lin

    (University of Chinese Academy of Sciences)

  • Qinglei Chong

    (University of Chinese Academy of Sciences)

  • Zhihan Zhang

    (Central China Normal University)

  • Fanke Meng

    (University of Chinese Academy of Sciences
    Nankai University
    University of Chinese Academy of Sciences)

Abstract

Catalytic enantioselective introduction of a propargyl group constitutes one of the most important carbon–carbon forming reactions, as it is versatile to be transformed into diverse functional groups and frequently used in the synthesis of natural products and biologically active molecules. Stereoconvergent transformations of racemic propargyl precursors to a single enantiomer of products via propargyl radicals represent a powerful strategy and provide new reactivity. However, only few Cu- or Ni-catalyzed protocols have been developed with limited reaction modes. Herein, a photoredox/cobalt-catalyzed regio-, diastereo- and enantioselective propargyl addition to aldehydes via propargyl radicals is presented, enabling construction of a broad scope of homopropargyl alcohols that are otherwise difficult to access in high efficiency and stereoselectivity from racemic propargyl carbonates. Mechanistic studies and DFT calculations provided evidence for the involvement of propargyl radicals, the origin of the stereoconvergent process and the stereochemical models.

Suggested Citation

  • Lei Wang & Chuiyi Lin & Qinglei Chong & Zhihan Zhang & Fanke Meng, 2023. "Photoredox cobalt-catalyzed regio-, diastereo- and enantioselective propargylation of aldehydes via propargyl radicals," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40488-3
    DOI: 10.1038/s41467-023-40488-3
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    Cited by:

    1. Jiangtao Ren & Zheng Sun & Shuang Zhao & Jinyuan Huang & Yukun Wang & Cheng Zhang & Jinhai Huang & Chenhao Zhang & Ruipu Zhang & Zhihan Zhang & Xu Ji & Zhihui Shao, 2024. "Enantioselective synthesis of chiral α,α-dialkyl indoles and related azoles by cobalt-catalyzed hydroalkylation and regioselectivity switch," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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