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A gut feeling for drugs that have metabolic benefits

Author

Listed:
  • Eryun Zhang

    (Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center)

  • Alon Agua

    (Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center)

  • Wendong Huang

    (Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
    City of Hope National Medical Center)

Abstract

Resveratrol (REV) is a natural polyphenol with anti-obesity effects. However, the mechanisms remain unclear due to its low bioavailability and the lack of defined membrane-bound or nuclear receptors. Pang and colleagues reported that REV intervention (REV-I) alters gut microbiota and bile acid profile, leading to the inhibition of farnesoid X receptor (FXR) and attenuation of scavenger receptor class B type 1 (SR-B1)-mediated chylomicron secretion. This highlights a therapeutic potential of targeting gut microbiome and intestinal SR-B1 for obesity and diabetes treatment.

Suggested Citation

  • Eryun Zhang & Alon Agua & Wendong Huang, 2023. "A gut feeling for drugs that have metabolic benefits," Nature Communications, Nature, vol. 14(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40167-3
    DOI: 10.1038/s41467-023-40167-3
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    1. Eryun Zhang & Lihua Jin & Yangmeng Wang & Jui Tu & Ruirong Zheng & Lili Ding & Zhipeng Fang & Mingjie Fan & Ismail Al-Abdullah & Rama Natarajan & Ke Ma & Zhengtao Wang & Arthur D. Riggs & Sarah C. Shu, 2022. "Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Yifei Zhang & Yanyun Gu & Huahui Ren & Shujie Wang & Huanzi Zhong & Xinjie Zhao & Jing Ma & Xuejiang Gu & Yaoming Xue & Shan Huang & Jialin Yang & Li Chen & Gang Chen & Shen Qu & Jun Liang & Li Qin & , 2020. "Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
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