IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-40130-2.html
   My bibliography  Save this article

SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy

Author

Listed:
  • George Peat

    (University of Edinburgh)

  • Patrick J. Boaler

    (University of Edinburgh)

  • Claire L. Dickson

    (University of Edinburgh
    Oxford Instruments)

  • Guy C. Lloyd-Jones

    (University of Edinburgh)

  • Dušan Uhrín

    (University of Edinburgh)

Abstract

Since its discovery in mid-20th century, the sensitivity of Nuclear Magnetic Resonance (NMR) has increased steadily, in part due to the design of new, sophisticated NMR experiments. Here we report on a liquid-state NMR methodology that significantly increases the sensitivity of diffusion coefficient measurements of pure compounds, allowing to estimate their sizes using a much reduced amount of material. In this method, the diffusion coefficients are being measured by analysing narrow and intense singlets, which are invariant to magnetic field inhomogeneities. The singlets are obtained through signal acquisition embedded in short (

Suggested Citation

  • George Peat & Patrick J. Boaler & Claire L. Dickson & Guy C. Lloyd-Jones & Dušan Uhrín, 2023. "SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40130-2
    DOI: 10.1038/s41467-023-40130-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-40130-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-40130-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Danhua Dai & Xianwei Wang & Yiwei Liu & Xiao-Liang Yang & Clemens Glaubitz & Vasyl Denysenkov & Xiao He & Thomas Prisner & Jiafei Mao, 2021. "Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Otto Mankinen & Vladimir V. Zhivonitko & Anne Selent & Sarah Mailhiot & Sanna Komulainen & Nønne L. Prisle & Susanna Ahola & Ville-Veikko Telkki, 2020. "Ultrafast diffusion exchange nuclear magnetic resonance," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    3. Susanna Ahola & Vladimir V Zhivonitko & Otto Mankinen & Guannan Zhang & Anu M. Kantola & Hsueh-Ying Chen & Christian Hilty & Igor V. Koptyug & Ville-Veikko Telkki, 2015. "Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis," Nature Communications, Nature, vol. 6(1), pages 1-7, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40130-2. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.