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Ultrafast diffusion exchange nuclear magnetic resonance

Author

Listed:
  • Otto Mankinen

    (University of Oulu)

  • Vladimir V. Zhivonitko

    (University of Oulu)

  • Anne Selent

    (University of Oulu)

  • Sarah Mailhiot

    (University of Oulu)

  • Sanna Komulainen

    (University of Oulu)

  • Nønne L. Prisle

    (University of Oulu)

  • Susanna Ahola

    (University of Oulu)

  • Ville-Veikko Telkki

    (University of Oulu)

Abstract

The exchange of molecules between different physical or chemical environments due to diffusion or chemical transformations has a crucial role in a plethora of fundamental processes such as breathing, protein folding, chemical reactions and catalysis. Here, we introduce a method for a single-scan, ultrafast NMR analysis of molecular exchange based on the diffusion coefficient contrast. The method shortens the experiment time by one to four orders of magnitude. Consequently, it opens the way for high sensitivity quantification of important transient physical and chemical exchange processes such as in cellular metabolism. As a proof of principle, we demonstrate that the method reveals the structure of aggregates formed by surfactants relevant to aerosol research.

Suggested Citation

  • Otto Mankinen & Vladimir V. Zhivonitko & Anne Selent & Sarah Mailhiot & Sanna Komulainen & Nønne L. Prisle & Susanna Ahola & Ville-Veikko Telkki, 2020. "Ultrafast diffusion exchange nuclear magnetic resonance," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17079-7
    DOI: 10.1038/s41467-020-17079-7
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    Cited by:

    1. George Peat & Patrick J. Boaler & Claire L. Dickson & Guy C. Lloyd-Jones & Dušan Uhrín, 2023. "SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy," Nature Communications, Nature, vol. 14(1), pages 1-8, December.

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