IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-40079-2.html
   My bibliography  Save this article

Association between vmPFC gray matter volume and smoking initiation in adolescents

Author

Listed:
  • Shitong Xiang

    (Fudan University
    Ministry of Education)

  • Tianye Jia

    (Fudan University
    Ministry of Education
    Fudan University
    King’s College London)

  • Chao Xie

    (Fudan University
    Ministry of Education)

  • Wei Cheng

    (Fudan University
    Ministry of Education)

  • Bader Chaarani

    (University of Vermont)

  • Tobias Banaschewski

    (Medical Faculty Mannheim, Heidelberg University)

  • Gareth J. Barker

    (King’s College London)

  • Arun L. W. Bokde

    (Trinity College Dublin)

  • Christian Büchel

    (University Medical Centre Hamburg-Eppendorf)

  • Sylvane Desrivières

    (King’s College London)

  • Herta Flor

    (Heidelberg University
    School of Social Sciences, University of Mannheim)

  • Antoine Grigis

    (Université Paris-Saclay)

  • Penny A. Gowland

    (University of Nottingham)

  • Rüdiger Brühl

    (Physikalisch-Technische Bundesanstalt (PTB))

  • Jean-Luc Martinot

    (Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010)

  • Marie-Laure Paillère Martinot

    (Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010
    AP-HP, Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital)

  • Frauke Nees

    (Medical Faculty Mannheim, Heidelberg University
    Heidelberg University
    University Medical Center Schleswig-Holstein, Kiel University)

  • Dimitri Papadopoulos Orfanos

    (School of Social Sciences, University of Mannheim)

  • Luise Poustka

    (Center for Psychosocial Medicine, University Hospital Heidelberg)

  • Sarah Hohmann

    (Medical Faculty Mannheim, Heidelberg University)

  • Juliane H. Fröhner

    (Technische Universität Dresden)

  • Michael N. Smolka

    (Technische Universität Dresden)

  • Nilakshi Vaidya

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Henrik Walter

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Robert Whelan

    (Trinity College Dublin)

  • Hugh Garavan

    (University of Vermont)

  • Gunter Schumann

    (Fudan University
    Fudan University
    Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health
    Charité University Medicine Berlin)

  • Barbara J. Sahakian

    (Fudan University
    University of Cambridge)

  • Trevor W. Robbins

    (Fudan University
    University of Cambridge)

  • Jianfeng Feng

    (Fudan University
    Ministry of Education
    University of Warwick
    Zhangjiang Fudan International Innovation Center)

Abstract

Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.

Suggested Citation

  • Shitong Xiang & Tianye Jia & Chao Xie & Wei Cheng & Bader Chaarani & Tobias Banaschewski & Gareth J. Barker & Arun L. W. Bokde & Christian Büchel & Sylvane Desrivières & Herta Flor & Antoine Grigis & , 2023. "Association between vmPFC gray matter volume and smoking initiation in adolescents," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40079-2
    DOI: 10.1038/s41467-023-40079-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-40079-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-40079-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Stephen Burgess & Christopher N Foley & Elias Allara & James R Staley & Joanna M. M. Howson, 2020. "A robust and efficient method for Mendelian randomization with hundreds of genetic variants," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. James P. Pirruccello & Paolo Achille & Seung Hoan Choi & Joel T. Rämö & Shaan Khurshid & Mahan Nekoui & Sean J. Jurgens & Victor Nauffal & Shinwan Kany & Kenney Ng & Samuel F. Friedman & Puneet Batra , 2024. "Deep learning of left atrial structure and function provides link to atrial fibrillation risk," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Yihe Yang & Noah Lorincz-Comi & Xiaofeng Zhu, 2023. "Unbiased estimation and asymptotically valid inference in multivariable Mendelian randomization with many weak instrumental variables," Papers 2301.05130, arXiv.org, revised Feb 2024.
    3. Mattia Marchi & Anne Alkema & Charley Xia & Chris H. L. Thio & Li-Yu Chen & Winni Schalkwijk & Gian M. Galeazzi & Silvia Ferrari & Luca Pingani & Hyeokmoon Kweon & Sara Evans-Lacko & W. David Hill & M, 2024. "Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization," Nature Human Behaviour, Nature, vol. 8(9), pages 1771-1783, September.
    4. Ruoyu Wang & Qihua Wang & Wang Miao, 2023. "A robust fusion-extraction procedure with summary statistics in the presence of biased sources," Biometrika, Biometrika Trust, vol. 110(4), pages 1023-1040.
    5. Zhaonan Qu & Yongchan Kwon, 2024. "Distributionally Robust Instrumental Variables Estimation," Papers 2410.15634, arXiv.org.
    6. Yuanyuan Yu & Lei Hou & Xu Shi & Xiaoru Sun & Xinhui Liu & Yifan Yu & Zhongshang Yuan & Hongkai Li & Fuzhong Xue, 2022. "Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization methods," PLOS Genetics, Public Library of Science, vol. 18(3), pages 1-21, March.
    7. Daniel J. Benjamin & David Cesarini & Patrick Turley & Alexander Strudwick Young, 2024. "Social-Science Genomics: Progress, Challenges, and Future Directions," NBER Working Papers 32404, National Bureau of Economic Research, Inc.
    8. Lingyan Chen & James E. Peters & Bram Prins & Elodie Persyn & Matthew Traylor & Praveen Surendran & Savita Karthikeyan & Ekaterina Yonova-Doing & Emanuele Angelantonio & David J. Roberts & Nicholas A., 2022. "Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    9. Zhaotong Lin & Yangqing Deng & Wei Pan, 2021. "Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model," PLOS Genetics, Public Library of Science, vol. 17(11), pages 1-25, November.
    10. Qing Cheng & Xiao Zhang & Lin S. Chen & Jin Liu, 2022. "Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40079-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.