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Association between vmPFC gray matter volume and smoking initiation in adolescents

Author

Listed:
  • Shitong Xiang

    (Fudan University
    Ministry of Education)

  • Tianye Jia

    (Fudan University
    Ministry of Education
    Fudan University
    King’s College London)

  • Chao Xie

    (Fudan University
    Ministry of Education)

  • Wei Cheng

    (Fudan University
    Ministry of Education)

  • Bader Chaarani

    (University of Vermont)

  • Tobias Banaschewski

    (Medical Faculty Mannheim, Heidelberg University)

  • Gareth J. Barker

    (King’s College London)

  • Arun L. W. Bokde

    (Trinity College Dublin)

  • Christian Büchel

    (University Medical Centre Hamburg-Eppendorf)

  • Sylvane Desrivières

    (King’s College London)

  • Herta Flor

    (Heidelberg University
    School of Social Sciences, University of Mannheim)

  • Antoine Grigis

    (Université Paris-Saclay)

  • Penny A. Gowland

    (University of Nottingham)

  • Rüdiger Brühl

    (Physikalisch-Technische Bundesanstalt (PTB))

  • Jean-Luc Martinot

    (Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010)

  • Marie-Laure Paillère Martinot

    (Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS UMR9010
    AP-HP, Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital)

  • Frauke Nees

    (Medical Faculty Mannheim, Heidelberg University
    Heidelberg University
    University Medical Center Schleswig-Holstein, Kiel University)

  • Dimitri Papadopoulos Orfanos

    (School of Social Sciences, University of Mannheim)

  • Luise Poustka

    (Center for Psychosocial Medicine, University Hospital Heidelberg)

  • Sarah Hohmann

    (Medical Faculty Mannheim, Heidelberg University)

  • Juliane H. Fröhner

    (Technische Universität Dresden)

  • Michael N. Smolka

    (Technische Universität Dresden)

  • Nilakshi Vaidya

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Henrik Walter

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Robert Whelan

    (Trinity College Dublin)

  • Hugh Garavan

    (University of Vermont)

  • Gunter Schumann

    (Fudan University
    Fudan University
    Charité–Universitätsmedizin Berlin, corporate member of Freie Universität BerlinHumboldt-Universität zu Berlin, and Berlin Institute of Health
    Charité University Medicine Berlin)

  • Barbara J. Sahakian

    (Fudan University
    University of Cambridge)

  • Trevor W. Robbins

    (Fudan University
    University of Cambridge)

  • Jianfeng Feng

    (Fudan University
    Ministry of Education
    University of Warwick
    Zhangjiang Fudan International Innovation Center)

Abstract

Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.

Suggested Citation

  • Shitong Xiang & Tianye Jia & Chao Xie & Wei Cheng & Bader Chaarani & Tobias Banaschewski & Gareth J. Barker & Arun L. W. Bokde & Christian Büchel & Sylvane Desrivières & Herta Flor & Antoine Grigis & , 2023. "Association between vmPFC gray matter volume and smoking initiation in adolescents," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40079-2
    DOI: 10.1038/s41467-023-40079-2
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    References listed on IDEAS

    as
    1. Stephen Burgess & Christopher N Foley & Elias Allara & James R Staley & Joanna M. M. Howson, 2020. "A robust and efficient method for Mendelian randomization with hundreds of genetic variants," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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