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Origin of minicircular mitochondrial genomes in red algae

Author

Listed:
  • Yongsung Lee

    (Sungkyunkwan University)

  • Chung Hyun Cho

    (Sungkyunkwan University)

  • Chanyoung Noh

    (Sogang University)

  • Ji Hyun Yang

    (Sungkyunkwan University)

  • Seung In Park

    (Sungkyunkwan University)

  • Yu Min Lee

    (Sungkyunkwan University)

  • John A. West

    (University of Melbourne, Parkville)

  • Debashish Bhattacharya

    (Rutgers University)

  • Kyubong Jo

    (Sogang University)

  • Hwan Su Yoon

    (Sungkyunkwan University)

Abstract

Eukaryotic organelle genomes are generally of conserved size and gene content within phylogenetic groups. However, significant variation in genome structure may occur. Here, we report that the Stylonematophyceae red algae contain multipartite circular mitochondrial genomes (i.e., minicircles) which encode one or two genes bounded by a specific cassette and a conserved constant region. These minicircles are visualized using fluorescence microscope and scanning electron microscope, proving the circularity. Mitochondrial gene sets are reduced in these highly divergent mitogenomes. Newly generated chromosome-level nuclear genome assembly of Rhodosorus marinus reveals that most mitochondrial ribosomal subunit genes are transferred to the nuclear genome. Hetero-concatemers that resulted from recombination between minicircles and unique gene inventory that is responsible for mitochondrial genome stability may explain how the transition from typical mitochondrial genome to minicircles occurs. Our results offer inspiration on minicircular organelle genome formation and highlight an extreme case of mitochondrial gene inventory reduction.

Suggested Citation

  • Yongsung Lee & Chung Hyun Cho & Chanyoung Noh & Ji Hyun Yang & Seung In Park & Yu Min Lee & John A. West & Debashish Bhattacharya & Kyubong Jo & Hwan Su Yoon, 2023. "Origin of minicircular mitochondrial genomes in red algae," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39084-2
    DOI: 10.1038/s41467-023-39084-2
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    References listed on IDEAS

    as
    1. Rozbeh Baradaran & John M. Berrisford & Gurdeep S. Minhas & Leonid A. Sazanov, 2013. "Crystal structure of the entire respiratory complex I," Nature, Nature, vol. 494(7438), pages 443-448, February.
    2. Chung Hyun Cho & Seung In Park & Tzu-Yen Huang & Yongsung Lee & Claudia Ciniglia & Hari Chandana Yadavalli & Seong Wook Yang & Debashish Bhattacharya & Hwan Su Yoon, 2023. "Genome-wide signatures of adaptation to extreme environments in red algae," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
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