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Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation

Author

Listed:
  • Kaitlin R. Taibl

    (Emory University)

  • Anne L. Dunlop

    (Emory University)

  • Dana Boyd Barr

    (Emory University)

  • Yuan-Yuan Li

    (University of North Carolina)

  • Stephanie M. Eick

    (Emory University)

  • Kurunthachalam Kannan

    (New York University School of Medicine
    New York University School of Medicine)

  • P. Barry Ryan

    (Emory University)

  • Madison Schroder

    (University of North Carolina)

  • Blake Rushing

    (University of North Carolina)

  • Timothy Fennell

    (RTI International, Research Triangle Park)

  • Che-Jung Chang

    (Emory University)

  • Youran Tan

    (Emory University)

  • Carmen J. Marsit

    (Emory University)

  • Dean P. Jones

    (Emory University)

  • Donghai Liang

    (Emory University)

Abstract

Marginalized populations experience disproportionate rates of preterm birth and early term birth. Exposure to per- and polyfluoroalkyl substances (PFAS) has been reported to reduce length of gestation, but the underlying mechanisms are unknown. In the present study, we characterized the molecular signatures of prenatal PFAS exposure and gestational age at birth outcomes in the newborn dried blood spot metabolome among 267 African American dyads in Atlanta, Georgia between 2016 and 2020. Pregnant people with higher serum perfluorooctanoic acid and perfluorohexane sulfonic acid concentrations had increased odds of an early birth. After false discovery rate correction, the effect of prenatal PFAS exposure on reduced length of gestation was associated with 8 metabolomic pathways and 52 metabolites in newborn dried blood spots, which suggested perturbed tissue neogenesis, neuroendocrine function, and redox homeostasis. These mechanisms explain how prenatal PFAS exposure gives rise to the leading cause of infant death in the United States.

Suggested Citation

  • Kaitlin R. Taibl & Anne L. Dunlop & Dana Boyd Barr & Yuan-Yuan Li & Stephanie M. Eick & Kurunthachalam Kannan & P. Barry Ryan & Madison Schroder & Blake Rushing & Timothy Fennell & Che-Jung Chang & Yo, 2023. "Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38710-3
    DOI: 10.1038/s41467-023-38710-3
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    References listed on IDEAS

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    1. Qi Meng & Kosuke Inoue & Beate Ritz & Jørn Olsen & Zeyan Liew, 2018. "Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort," IJERPH, MDPI, vol. 15(9), pages 1-15, August.
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