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Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort

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  • Qi Meng

    (Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA)

  • Kosuke Inoue

    (Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA)

  • Beate Ritz

    (Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA)

  • Jørn Olsen

    (Department of Clinical Epidemiology, Aarhus University Hospital, N 8200 Aarhus, Denmark)

  • Zeyan Liew

    (Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA)

Abstract

Perfluoroalkyl substances (PFASs) are widespread industrial pollutants that are extremely persistent in the environment. A previous study in the Danish National Birth Cohort (DNBC) found prenatal perfluorooctanoate (PFOA) exposure was associated with decreased birth weight, but had insufficient statistical power to evaluate adverse birth outcomes. Here, we conducted additional analyses in three samples originating from the DNBC for 3535 mothers and infant pairs to evaluate associations between prenatal PFASs exposures and low birth weight and preterm birth. Maternal plasma concentrations were measured for six types of PFASs in early pregnancy. Several PFASs were associated with a reduction in birth weight and gestational age. We estimated a nearly 2-fold increase in risks of preterm birth for the higher quartiles of PFOA and perflourooctanesulfonate (PFOS) exposure. In spline models, risk of preterm birth was increased for perfluorononanoic acid (PFNA), perfluoroheptane sulfonate (PFHpS) and perfluorodecanoic acid (PFDA) in higher exposure ranges. We also observed some elevated risks for low birth weight but these estimates were less precise. Our findings strengthen the evidence that in-utero PFASs exposures affect fetal growth. Future studies are needed to evaluate whether these associations persist with the decline of PFOA and PFOS in populations and should also investigate newer types of fluorinated compounds introduced more recently.

Suggested Citation

  • Qi Meng & Kosuke Inoue & Beate Ritz & Jørn Olsen & Zeyan Liew, 2018. "Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort," IJERPH, MDPI, vol. 15(9), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:9:p:1832-:d:165646
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    References listed on IDEAS

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    1. Kristen M. Rappazzo & Evan Coffman & Erin P. Hines, 2017. "Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature," IJERPH, MDPI, vol. 14(7), pages 1-22, June.
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    Cited by:

    1. Karin Engström & Anna Axmon & Christel Nielsen & Anna Rignell-Hydbom, 2022. "High in Utero Exposure to Perfluoroalkyl Substances from Drinking Water and Birth Weight: A Cohort Study among Infants in Ronneby, Sweden," IJERPH, MDPI, vol. 19(4), pages 1-11, February.
    2. Kaitlin R. Taibl & Anne L. Dunlop & Dana Boyd Barr & Yuan-Yuan Li & Stephanie M. Eick & Kurunthachalam Kannan & P. Barry Ryan & Madison Schroder & Blake Rushing & Timothy Fennell & Che-Jung Chang & Yo, 2023. "Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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