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The impact of introduction of the 10-valent pneumococcal conjugate vaccine on pneumococcal carriage in Nigeria

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  • Aishatu L. Adamu

    (KEMRI-Wellcome Trust Research Programme
    London School of Hygiene & Tropical Medicine
    College of Health Sciences, Bayero University, Kano/Aminu Kano Teaching Hospital)

  • J. Ojal

    (KEMRI-Wellcome Trust Research Programme
    London School of Hygiene & Tropical Medicine)

  • Isa A. Abubakar

    (College of Health Sciences, Bayero University, Kano/Aminu Kano Teaching Hospital)

  • Kofo A. Odeyemi

    (College of Medicine, University of Lagos)

  • Musa M. Bello

    (College of Health Sciences, Bayero University, Kano/Aminu Kano Teaching Hospital)

  • Christy A. N. Okoromah

    (College of Medicine, University of Lagos)

  • Boniface Karia

    (KEMRI-Wellcome Trust Research Programme)

  • Angela Karani

    (KEMRI-Wellcome Trust Research Programme)

  • Donald. Akech

    (KEMRI-Wellcome Trust Research Programme)

  • Victor Inem

    (College of Medicine, University of Lagos)

  • J. Anthony G. Scott

    (KEMRI-Wellcome Trust Research Programme
    London School of Hygiene & Tropical Medicine)

  • Ifedayo M. O. Adetifa

    (KEMRI-Wellcome Trust Research Programme
    London School of Hygiene & Tropical Medicine
    College of Medicine, University of Lagos
    Nigeria Centre for Disease Control)

Abstract

Pneumococcal conjugate vaccines (PCVs) protect against invasive pneumococcal disease (IPD) among vaccinees. However, at population level, this protection is driven by indirect effects. PCVs prevent nasopharyngeal acquisition of vaccine-serotype (VT) pneumococci, reducing onward transmission. Each disease episode is preceded by infection from a carrier, so vaccine impacts on carriage provide a minimum estimate of disease reduction in settings lacking expensive IPD surveillance. We documented carriage prevalence and vaccine coverage in two settings in Nigeria annually (2016–2020) following PCV10 introduction in 2016. Among 4,684 rural participants, VT carriage prevalence fell from 21 to 12% as childhood (

Suggested Citation

  • Aishatu L. Adamu & J. Ojal & Isa A. Abubakar & Kofo A. Odeyemi & Musa M. Bello & Christy A. N. Okoromah & Boniface Karia & Angela Karani & Donald. Akech & Victor Inem & J. Anthony G. Scott & Ifedayo M, 2023. "The impact of introduction of the 10-valent pneumococcal conjugate vaccine on pneumococcal carriage in Nigeria," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38277-z
    DOI: 10.1038/s41467-023-38277-z
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    References listed on IDEAS

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    1. Daniel R Feikin & Eunice W Kagucia & Jennifer D Loo & Ruth Link-Gelles & Milo A Puhan & Thomas Cherian & Orin S Levine & Cynthia G Whitney & Katherine L O’Brien & Matthew R Moore & the Serotype Replac, 2013. "Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites," PLOS Medicine, Public Library of Science, vol. 10(9), pages 1-28, September.
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