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Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice

Author

Listed:
  • Jia-Ni Li

    (The Fourth Military Medical University)

  • Xue-Mei Wu

    (The Fourth Military Medical University
    Sichuan University)

  • Liu-Jie Zhao

    (The Fourth Military Medical University
    Zhengzhou University)

  • Han-Xue Sun

    (The Fourth Military Medical University
    Fujian Medical University)

  • Jie Hong

    (The Fourth Military Medical University
    Baotou Medical College Inner Mongolia University of Science and Technology)

  • Feng-Ling Wu

    (The Fourth Military Medical University
    Zhengzhou University)

  • Si-Hai Chen

    (The Fourth Military Medical University
    Zhengzhou University)

  • Tao Chen

    (The Fourth Military Medical University)

  • Hui Li

    (The Fourth Military Medical University)

  • Yu-Lin Dong

    (The Fourth Military Medical University)

  • Yun-Qing Li

    (The Fourth Military Medical University
    Sichuan University
    Zhengzhou University
    Fujian Medical University)

Abstract

Itch is an annoying sensation consisting of both sensory and emotional components. It is known to involve the parabrachial nucleus (PBN), but the following transmission nodes remain elusive. The present study identified that the PBN-central medial thalamic nucleus (CM)-medial prefrontal cortex (mPFC) pathway is essential for itch signal transmission at the supraspinal level in male mice. Chemogenetic inhibition of the CM-mPFC pathway attenuates scratching behavior or chronic itch-related affective responses. CM input to mPFC pyramidal neurons is enhanced in acute and chronic itch models. Specifically chronic itch stimuli also alter mPFC interneuron involvement, resulting in enhanced feedforward inhibition and a distorted excitatory/inhibitory balance in mPFC pyramidal neurons. The present work underscores CM as a transmit node of the itch signal in the thalamus, which is dynamically engaged in both the sensory and affective dimensions of itch with different stimulus salience.

Suggested Citation

  • Jia-Ni Li & Xue-Mei Wu & Liu-Jie Zhao & Han-Xue Sun & Jie Hong & Feng-Ling Wu & Si-Hai Chen & Tao Chen & Hui Li & Yu-Lin Dong & Yun-Qing Li, 2023. "Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38264-4
    DOI: 10.1038/s41467-023-38264-4
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    References listed on IDEAS

    as
    1. Xiao-Jun Chen & Yan-Gang Sun, 2020. "Central circuit mechanisms of itch," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. Hai-Ying Liang & Zhi-Jin Chen & Hui Xiao & Yu-Hui Lin & Ying-Yi Hu & Lei Chang & Hai-Yin Wu & Peng Wang & Wei Lu & Dong-Ya Zhu & Chun-Xia Luo, 2020. "nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors," Nature Communications, Nature, vol. 11(1), pages 1-18, December.
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