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Central circuit mechanisms of itch

Author

Listed:
  • Xiao-Jun Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yan-Gang Sun

    (Chinese Academy of Sciences
    Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology)

Abstract

Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and supraspinal levels. Major components of the spinal neural circuit underlying both chemical and mechanical itch have now been identified, along with the circuits relaying ascending transmission and the descending modulation of itch. In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels.

Suggested Citation

  • Xiao-Jun Chen & Yan-Gang Sun, 2020. "Central circuit mechanisms of itch," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16859-5
    DOI: 10.1038/s41467-020-16859-5
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    Cited by:

    1. Jia-Ni Li & Xue-Mei Wu & Liu-Jie Zhao & Han-Xue Sun & Jie Hong & Feng-Ling Wu & Si-Hai Chen & Tao Chen & Hui Li & Yu-Lin Dong & Yun-Qing Li, 2023. "Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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