IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-38210-4.html
   My bibliography  Save this article

A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis

Author

Listed:
  • Jinsheng Tang

    (Nanjing Agricultural University)

  • Mengru Guo

    (Nanjing Agricultural University)

  • Min Chen

    (Nanjing Agricultural University)

  • Bin Xu

    (Jiangsu Academy of Agricultural Sciences)

  • Tingting Ran

    (Nanjing Agricultural University)

  • Weiwu Wang

    (Nanjing Agricultural University)

  • Zhe Ma

    (Nanjing Agricultural University
    Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses)

  • Huixing Lin

    (Nanjing Agricultural University
    Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses)

  • Hongjie Fan

    (Nanjing Agricultural University
    Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses)

Abstract

Synthesis of capsular polysaccharide (CPS), an important virulence factor of pathogenic bacteria, is modulated by the CpsBCD phosphoregulatory system in Streptococcus. Serine/threonine kinases (STKs, e.g. Stk1) can also regulate CPS synthesis, but the underlying mechanisms are unclear. Here, we identify a protein (CcpS) that is phosphorylated by Stk1 and modulates the activity of phosphatase CpsB in Streptococcus suis, thus linking Stk1 to CPS synthesis. The crystal structure of CcpS shows an intrinsically disordered region at its N-terminus, including two threonine residues that are phosphorylated by Stk1. The activity of phosphatase CpsB is inhibited when bound to non-phosphorylated CcpS. Thus, CcpS modulates the activity of phosphatase CpsB thereby altering CpsD phosphorylation, which in turn modulates the expression of the Wzx-Wzy pathway and thus CPS production.

Suggested Citation

  • Jinsheng Tang & Mengru Guo & Min Chen & Bin Xu & Tingting Ran & Weiwu Wang & Zhe Ma & Huixing Lin & Hongjie Fan, 2023. "A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38210-4
    DOI: 10.1038/s41467-023-38210-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-38210-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-38210-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Robert M. Cleverley & Zoe J. Rutter & Jeanine Rismondo & Federico Corona & Ho-Ching Tiffany Tsui & Fuad A. Alatawi & Richard A. Daniel & Sven Halbedel & Orietta Massidda & Malcolm E. Winkler & Richard, 2019. "The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    2. Yun Yang & Jiwei Liu & Bradley R. Clarke & Laura Seidel & Jani R. Bolla & Philip N. Ward & Peijun Zhang & Carol V. Robinson & Chris Whitfield & James H. Naismith, 2021. "The molecular basis of regulation of bacterial capsule assembly by Wzc," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Marvin Rausch & Julia P. Deisinger & Hannah Ulm & Anna Müller & Wenjin Li & Patrick Hardt & Xiaogang Wang & Xue Li & Marc Sylvester & Marianne Engeser & Waldemar Vollmer & Christa E. Müller & Hans Geo, 2019. "Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Rei Nakamoto & Sarp Bamyaci & Karin Blomqvist & Staffan Normark & Birgitta Henriques-Normark & Lok-To Sham, 2023. "The divisome but not the elongasome organizes capsule synthesis in Streptococcus pneumoniae," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Amandine Nucci & Eduardo P. C. Rocha & Olaya Rendueles, 2022. "Adaptation to novel spatially-structured environments is driven by the capsule and alters virulence-associated traits," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38210-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.