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A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis

Author

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  • Jinsheng Tang

    (Nanjing Agricultural University)

  • Mengru Guo

    (Nanjing Agricultural University)

  • Min Chen

    (Nanjing Agricultural University)

  • Bin Xu

    (Jiangsu Academy of Agricultural Sciences)

  • Tingting Ran

    (Nanjing Agricultural University)

  • Weiwu Wang

    (Nanjing Agricultural University)

  • Zhe Ma

    (Nanjing Agricultural University
    Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses)

  • Huixing Lin

    (Nanjing Agricultural University
    Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses)

  • Hongjie Fan

    (Nanjing Agricultural University
    Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses)

Abstract

Synthesis of capsular polysaccharide (CPS), an important virulence factor of pathogenic bacteria, is modulated by the CpsBCD phosphoregulatory system in Streptococcus. Serine/threonine kinases (STKs, e.g. Stk1) can also regulate CPS synthesis, but the underlying mechanisms are unclear. Here, we identify a protein (CcpS) that is phosphorylated by Stk1 and modulates the activity of phosphatase CpsB in Streptococcus suis, thus linking Stk1 to CPS synthesis. The crystal structure of CcpS shows an intrinsically disordered region at its N-terminus, including two threonine residues that are phosphorylated by Stk1. The activity of phosphatase CpsB is inhibited when bound to non-phosphorylated CcpS. Thus, CcpS modulates the activity of phosphatase CpsB thereby altering CpsD phosphorylation, which in turn modulates the expression of the Wzx-Wzy pathway and thus CPS production.

Suggested Citation

  • Jinsheng Tang & Mengru Guo & Min Chen & Bin Xu & Tingting Ran & Weiwu Wang & Zhe Ma & Huixing Lin & Hongjie Fan, 2023. "A link between STK signalling and capsular polysaccharide synthesis in Streptococcus suis," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38210-4
    DOI: 10.1038/s41467-023-38210-4
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    References listed on IDEAS

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    1. Robert M. Cleverley & Zoe J. Rutter & Jeanine Rismondo & Federico Corona & Ho-Ching Tiffany Tsui & Fuad A. Alatawi & Richard A. Daniel & Sven Halbedel & Orietta Massidda & Malcolm E. Winkler & Richard, 2019. "The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    2. Marvin Rausch & Julia P. Deisinger & Hannah Ulm & Anna Müller & Wenjin Li & Patrick Hardt & Xiaogang Wang & Xue Li & Marc Sylvester & Marianne Engeser & Waldemar Vollmer & Christa E. Müller & Hans Geo, 2019. "Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    3. Yun Yang & Jiwei Liu & Bradley R. Clarke & Laura Seidel & Jani R. Bolla & Philip N. Ward & Peijun Zhang & Carol V. Robinson & Chris Whitfield & James H. Naismith, 2021. "The molecular basis of regulation of bacterial capsule assembly by Wzc," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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