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Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice

Author

Listed:
  • Ya-Wei Ji

    (Xuzhou Medical University)

  • Zi-Lin Shen

    (Xuzhou Medical University)

  • Xue Zhang

    (Xuzhou Medical University)

  • Kairan Zhang

    (Xuzhou Medical University)

  • Tao Jia

    (Xuzhou Medical University)

  • Xiangying Xu

    (Xuzhou Medical University)

  • Huizhen Geng

    (Xuzhou Medical University)

  • Yu Han

    (Xuzhou Medical University)

  • Cui Yin

    (Xuzhou Medical University
    Xuzhou Medical University
    Xuzhou Medical University)

  • Jian-Jun Yang

    (The First Affiliated Hospital of Zhengzhou University)

  • Jun-Li Cao

    (Xuzhou Medical University
    Xuzhou Medical University
    Xuzhou Medical University)

  • Chunyi Zhou

    (Xuzhou Medical University
    Xuzhou Medical University
    Xuzhou Medical University)

  • Cheng Xiao

    (Xuzhou Medical University
    Xuzhou Medical University
    Xuzhou Medical University)

Abstract

Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like and depression-like behaviour. As the ventral pallidum (VP) in the BF regulates pain perception and emotions, we aim to address the role of VP-derived cholinergic circuits in hyperalgesia and depression-like behaviour in chronic pain mouse model. In male mice, VP cholinergic neurons innervate local non-cholinergic neurons and modulate downstream basolateral amygdala (BLA) neurons through nicotinic acetylcholine receptors. These cholinergic circuits are mobilized by pain-like stimuli and become hyperactive during persistent pain. Acute stimulation of VP cholinergic neurons and the VP-BLA cholinergic projection reduces pain threshold in naïve mice whereas inhibition of the circuits elevated pain threshold in pain-like states. Multi-day repetitive modulation of the VP-BLA cholinergic pathway regulates depression-like behaviour in persistent pain. Therefore, VP-derived cholinergic circuits are implicated in comorbid hyperalgesia and depression-like behaviour in chronic pain mouse model.

Suggested Citation

  • Ya-Wei Ji & Zi-Lin Shen & Xue Zhang & Kairan Zhang & Tao Jia & Xiangying Xu & Huizhen Geng & Yu Han & Cui Yin & Jian-Jun Yang & Jun-Li Cao & Chunyi Zhou & Cheng Xiao, 2023. "Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37968-x
    DOI: 10.1038/s41467-023-37968-x
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    References listed on IDEAS

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    1. Wei-Zhu Liu & Wen-Hua Zhang & Zhi-Heng Zheng & Jia-Xin Zou & Xiao-Xuan Liu & Shou-He Huang & Wen-Jie You & Ye He & Jun-Yu Zhang & Xiao-Dong Wang & Bing-Xing Pan, 2020. "Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    2. Eun-Hwa Lee & Jin-Young Park & Hye-Jin Kwon & Pyung-Lim Han, 2021. "Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Tao Jia & Ying-Di Wang & Jing Chen & Xue Zhang & Jun-Li Cao & Cheng Xiao & Chunyi Zhou, 2022. "A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Lauren Faget & Vivien Zell & Elizabeth Souter & Adam McPherson & Reed Ressler & Navarre Gutierrez-Reed & Ji Hoon Yoo & Davide Dulcis & Thomas S. Hnasko, 2018. "Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
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