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Effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17

Author

Listed:
  • Francisco Tsz Tsun Lai

    (The University of Hong Kong
    Hong Kong Science Park)

  • Min Fan

    (The University of Hong Kong)

  • Caige Huang

    (The University of Hong Kong)

  • Celine Sze Ling Chui

    (Hong Kong Science Park
    University of Hong Kong
    University of Hong Kong)

  • Eric Yuk Fai Wan

    (The University of Hong Kong
    Hong Kong Science Park
    University of Hong Kong)

  • Xue Li

    (The University of Hong Kong
    Hong Kong Science Park
    University of Hong Kong)

  • Carlos King Ho Wong

    (The University of Hong Kong
    Hong Kong Science Park
    University of Hong Kong)

  • Ching-Lung Cheung

    (The University of Hong Kong)

  • Ian Chi Kei Wong

    (The University of Hong Kong)

  • Esther Wai Yin Chan

    (The University of Hong Kong
    Hong Kong Science Park)

Abstract

Extended intervals between the first and second doses of mRNA Covid-19 vaccines may reduce the risk of myocarditis in children and adolescents. However, vaccine effectiveness after this extension remains unclear. To examine this potential variable effectiveness, we conducted a population-based nested case-control study of children and adolescents aged 5–17 years who had received two doses of BNT162b2 in Hong Kong. From January 1 to August 15, 2022, 5396 Covid-19 cases and 202 Covid-19 related hospitalizations were identified and matched with 21,577 and 808 controls, respectively. For vaccine recipients with extended intervals [≥28 days, adjusted odds ratio 0.718, 95% Confidence Interval: 0.619, 0.833] there was a 29.2%-reduced risk of Covid-19 infection compared to those with regular intervals (21–27 days). If the threshold was set at eight weeks, the risk reduction was estimated at 43.5% (aOR 0.565, 95% CI: 0.456, 0.700). In conclusion, longer dosing intervals for children and adolescents should be considered.

Suggested Citation

  • Francisco Tsz Tsun Lai & Min Fan & Caige Huang & Celine Sze Ling Chui & Eric Yuk Fai Wan & Xue Li & Carlos King Ho Wong & Ching-Lung Cheung & Ian Chi Kei Wong & Esther Wai Yin Chan, 2023. "Effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17," Nature Communications, Nature, vol. 14(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37556-z
    DOI: 10.1038/s41467-023-37556-z
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    References listed on IDEAS

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    1. Gayatri Amirthalingam & Jamie Lopez Bernal & Nick J. Andrews & Heather Whitaker & Charlotte Gower & Julia Stowe & Elise Tessier & Sathyavani Subbarao & Georgina Ireland & Frances Baawuah & Ezra Linley, 2021. "Serological responses and vaccine effectiveness for extended COVID-19 vaccine schedules in England," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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