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Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers

Author

Listed:
  • Ulrika Marking

    (Karolinska Institutet Danderyd Hospital)

  • Sebastian Havervall

    (Karolinska Institutet Danderyd Hospital)

  • Nina Greilert Norin

    (Karolinska Institutet Danderyd Hospital)

  • Oscar Bladh

    (Karolinska Institutet Danderyd Hospital)

  • Wanda Christ

    (Karolinska Institutet)

  • Max Gordon

    (Karolinska Institutet Danderyd Hospital)

  • Henry Ng

    (Uppsala University)

  • Kim Blom

    (Karolinska Institutet Danderyd Hospital)

  • Mia Phillipson

    (Uppsala University)

  • Sara Mangsbo

    (Uppsala University)

  • Jessica J. Alm

    (Karolinska Institutet)

  • Anna Smed-Sörensen

    (Karolinska Institutet, Karolinska University Hospital)

  • Peter Nilsson

    (KTH Royal Institute of Technology, SciLifeLab)

  • Sophia Hober

    (KTH Royal Institute of Technology, SciLifeLab)

  • Mikael Åberg

    (Uppsala University)

  • Jonas Klingström

    (Karolinska Institutet
    Linköping University)

  • Charlotte Thålin

    (Karolinska Institutet Danderyd Hospital)

Abstract

Vaccination offers protection against severe COVID-19 caused by SARS-CoV-2 omicron but is less effective against infection. Characteristics such as serum antibody titer correlation to protection, viral abundance and clearance of omicron infection in vaccinated individuals are scarce. We present a 4-week twice-weekly SARS-CoV-2 qPCR screening in 368 triple vaccinated healthcare workers. Spike-specific IgG levels, neutralization titers and mucosal spike-specific IgA-levels were determined at study start and qPCR-positive participants were sampled repeatedly for two weeks. 81 (cumulative incidence 22%) BA.1, BA.1.1 and BA.2 infections were detected. High serum antibody titers are shown to be protective against infection (p

Suggested Citation

  • Ulrika Marking & Sebastian Havervall & Nina Greilert Norin & Oscar Bladh & Wanda Christ & Max Gordon & Henry Ng & Kim Blom & Mia Phillipson & Sara Mangsbo & Jessica J. Alm & Anna Smed-Sörensen & Peter, 2023. "Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36984-1
    DOI: 10.1038/s41467-023-36984-1
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    References listed on IDEAS

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    1. Ann-Sofie Rudberg & Sebastian Havervall & Anna Månberg & August Jernbom Falk & Katherina Aguilera & Henry Ng & Lena Gabrielsson & Ann-Christin Salomonsson & Leo Hanke & Ben Murrell & Gerald McInerney , 2020. "SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
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