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Complementary peptides represent a credible alternative to agrochemicals by activating translation of targeted proteins

Author

Listed:
  • Mélanie Ormancey

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT)

  • Bruno Guillotin

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
    Micropep Technologies)

  • Rémy Merret

    (Laboratoire Génome et Développement des Plantes, CNRS/UPVD)

  • Laurent Camborde

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT)

  • Carine Duboé

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT)

  • Bertrand Fabre

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT)

  • Cécile Pouzet

    (Fédération de Recherche Agrobiosciences, Interactions et Biodiversité, UT3/CNRS)

  • Francis Impens

    (VIB Center for Medical Biotechnology
    VIB Proteomics Core
    Ghent University, Department of Biomolecular Medicine)

  • Delphi Haver

    (VIB Center for Medical Biotechnology
    VIB Proteomics Core
    Ghent University, Department of Biomolecular Medicine)

  • Marie-Christine Carpentier

    (Laboratoire Génome et Développement des Plantes, CNRS/UPVD)

  • Hélène San Clemente

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT)

  • Marielle Aguilar

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT)

  • Dominique Lauressergues

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
    Micropep Technologies)

  • Lars B. Scharff

    (University of Copenhagen, Department of Plant and Environmental Sciences)

  • Carole Pichereaux

    (Fédération de Recherche Agrobiosciences, Interactions et Biodiversité, UT3/CNRS
    Institut de Pharmacologie et de Biologie Structurale, CNRS/UT3
    Infrastructure nationale de protéomique, ProFI)

  • Odile Burlet-Schiltz

    (Institut de Pharmacologie et de Biologie Structurale, CNRS/UT3
    Infrastructure nationale de protéomique, ProFI)

  • Cécile Bousquet-Antonelli

    (Laboratoire Génome et Développement des Plantes, CNRS/UPVD)

  • Kris Gevaert

    (VIB Center for Medical Biotechnology
    Ghent University, Department of Biomolecular Medicine)

  • Patrice Thuleau

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT)

  • Serge Plaza

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT)

  • Jean-Philippe Combier

    (Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
    Micropep Technologies)

Abstract

The current agriculture main challenge is to maintain food production while facing multiple threats such as increasing world population, temperature increase, lack of agrochemicals due to health issues and uprising of weeds resistant to herbicides. Developing novel, alternative, and safe methods is hence of paramount importance. Here, we show that complementary peptides (cPEPs) from any gene can be designed to target specifically plant coding genes. External application of synthetic peptides increases the abundance of the targeted protein, leading to related phenotypes. Moreover, we provide evidence that cPEPs can be powerful tools in agronomy to improve plant traits, such as growth, resistance to pathogen or heat stress, without the needs of genetic approaches. Finally, by combining their activity they can also be used to reduce weed growth.

Suggested Citation

  • Mélanie Ormancey & Bruno Guillotin & Rémy Merret & Laurent Camborde & Carine Duboé & Bertrand Fabre & Cécile Pouzet & Francis Impens & Delphi Haver & Marie-Christine Carpentier & Hélène San Clemente &, 2023. "Complementary peptides represent a credible alternative to agrochemicals by activating translation of targeted proteins," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35951-0
    DOI: 10.1038/s41467-023-35951-0
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    References listed on IDEAS

    as
    1. Fabienne Maillet & Véréna Poinsot & Olivier André & Virginie Puech-Pagès & Alexandra Haouy & Monique Gueunier & Laurence Cromer & Delphine Giraudet & Damien Formey & Andreas Niebel & Eduardo Andres Ma, 2011. "Fungal lipochitooligosaccharide symbiotic signals in arbuscular mycorrhiza," Nature, Nature, vol. 469(7328), pages 58-63, January.
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