IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-35813-9.html
   My bibliography  Save this article

Phylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay

Author

Listed:
  • Gladys Estigarribia Sanabria

    (Instituto Regional de Investigación en Salud)

  • Guillermo Sequera

    (Instituto de Salud Global de Barcelona (ISGLOBAL)
    Ministerio de Salud Pública y Bienestar Social (MSPyBS))

  • Sarita Aguirre

    (Ministerio de Salud Pública y Bienestar Social (MSPyBS))

  • Julieta Méndez

    (Instituto Regional de Investigación en Salud)

  • Paulo César Pereira Santos

    (Federal University of Mato Grosso do Sul)

  • Natalie Weiler Gustafson

    (Ministerio de Salud Publica y Bienestar Social (MSPyBS))

  • Margarita Godoy

    (Ministerio de Salud Publica y Bienestar Social (MSPyBS))

  • Analía Ortiz

    (Instituto Regional de Investigación en Salud)

  • Cynthia Cespedes

    (Ministerio de Salud Pública y Bienestar Social (MSPyBS))

  • Gloria Martínez

    (Instituto Regional de Investigación en Salud)

  • Alberto L. García-Basteiro

    (Instituto de Salud Global de Barcelona (ISGLOBAL)
    Centro de Investigação em Saude de Manhiça (CISM)
    Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC))

  • Jason R. Andrews

    (Stanford University School of Medicine)

  • Julio Croda

    (Federal University of Mato Grosso do Sul - UFMS
    Oswaldo Cruz Foundation Mato Grosso do Sul
    Yale School of Public Health)

  • Katharine S. Walter

    (University of Utah)

Abstract

Recent rises in incident tuberculosis (TB) cases in Paraguay and the increasing concentration of TB within prisons highlight the urgency of targeting strategies to interrupt transmission and prevent new infections. However, whether specific cities or carceral institutions play a disproportionate role in transmission remains unknown. We conducted prospective genomic surveillance, sequencing 471 Mycobacterium tuberculosis complex genomes, from inside and outside prisons in Paraguay’s two largest urban areas, Asunción and Ciudad del Este, from 2016 to 2021. We found genomic evidence of frequent recent transmission within prisons and transmission linkages spanning prisons and surrounding populations. We identified a signal of frequent M. tuberculosis spread between urban areas and marked recent population size expansion of the three largest genomic transmission clusters. Together, our findings highlight the urgency of strengthening TB control programs to reduce transmission risk within prisons in Paraguay, where incidence was 70 times that outside prisons in 2021.

Suggested Citation

  • Gladys Estigarribia Sanabria & Guillermo Sequera & Sarita Aguirre & Julieta Méndez & Paulo César Pereira Santos & Natalie Weiler Gustafson & Margarita Godoy & Analía Ortiz & Cynthia Cespedes & Gloria , 2023. "Phylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35813-9
    DOI: 10.1038/s41467-023-35813-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-35813-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-35813-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Arturo Torres Ortiz & Jorge Coronel & Julia Rios Vidal & Cesar Bonilla & David A. J. Moore & Robert H. Gilman & Francois Balloux & Onn Min Kon & Xavier Didelot & Louis Grandjean, 2021. "Genomic signatures of pre-resistance in Mycobacterium tuberculosis," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chloé Loiseau & Etthel M. Windels & Sebastian M. Gygli & Levan Jugheli & Nino Maghradze & Daniela Brites & Amanda Ross & Galo Goig & Miriam Reinhard & Sonia Borrell & Andrej Trauner & Anna Dötsch & Ru, 2023. "The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35813-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.