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Optical-resolution functional gastrointestinal photoacoustic endoscopy based on optical heterodyne detection of ultrasound

Author

Listed:
  • Yizhi Liang

    (Jinan University)

  • Wubing Fu

    (Jinan University)

  • Qiang Li

    (Jinan University)

  • Xiaolong Chen

    (Jinan University)

  • Huojiao Sun

    (Jinan University)

  • Lidai Wang

    (City University of Hong Kong)

  • Long Jin

    (Jinan University)

  • Wei Huang

    (Jinan University)

  • Bai-Ou Guan

    (Jinan University)

Abstract

Photoacoustic endoscopy shows promise in the detection of gastrointestinal cancer, inflammation, and other lesions. High-resolution endoscopic imaging of the hemodynamic response necessitates a small-sized, high-sensitivity ultrasound sensor. Here, we utilize a laser ultrasound sensor to develop a miniaturized, optical-resolution photoacoustic endoscope. The sensor can boost the acoustic response by a gain factor of ωo/Ω (the frequency ratio of the signal light and measured ultrasound) by measuring the acoustically induced optical phase change. As a result, we achieve a noise-equivalent pressure density (NEPD) below 1.5 mPa·Hz−1/2 over the measured range of 5 to 25 MHz. The heterodyne phase detection using dual-frequency laser beams of the sensor can offer resistance to thermal drift and vibrational perturbations. The endoscope is used to in vivo image a rat rectum and visualize the oxygen saturation changes during acute inflammation, which can hardly be observed with other imaging modalities.

Suggested Citation

  • Yizhi Liang & Wubing Fu & Qiang Li & Xiaolong Chen & Huojiao Sun & Lidai Wang & Long Jin & Wei Huang & Bai-Ou Guan, 2022. "Optical-resolution functional gastrointestinal photoacoustic endoscopy based on optical heterodyne detection of ultrasound," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35259-5
    DOI: 10.1038/s41467-022-35259-5
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    References listed on IDEAS

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    1. Rami Shnaiderman & Georg Wissmeyer & Okan Ülgen & Qutaiba Mustafa & Andriy Chmyrov & Vasilis Ntziachristos, 2020. "A submicrometre silicon-on-insulator resonator for ultrasound detection," Nature, Nature, vol. 585(7825), pages 372-378, September.
    2. Thibault Wildi & Thibault Voumard & Victor Brasch & Gürkan Yilmaz & Tobias Herr, 2020. "Photo-acoustic dual-frequency comb spectroscopy," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
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