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Regulating voltage-gated ion channels with nanobodies

Author

Listed:
  • Declan Manning

    (University of California, Davis, One Shields Avenue)

  • L. Fernando Santana

    (University of California, Davis, One Shields Avenue)

Abstract

In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca2+ channels associated with β1 subunits and promote their removal from the surface membrane of neurons and muscle.

Suggested Citation

  • Declan Manning & L. Fernando Santana, 2022. "Regulating voltage-gated ion channels with nanobodies," Nature Communications, Nature, vol. 13(1), pages 1-2, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35027-5
    DOI: 10.1038/s41467-022-35027-5
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    References listed on IDEAS

    as
    1. Travis J. Morgenstern & Neha Nirwan & Erick O. Hernández-Ochoa & Hugo Bibollet & Papiya Choudhury & Yianni D. Laloudakis & Manu Johny & Roger A. Bannister & Martin F. Schneider & Daniel L. Minor & Hen, 2022. "Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Guoxia Liu & Arianne Papa & Alexander N. Katchman & Sergey I. Zakharov & Daniel Roybal & Jessica A. Hennessey & Jared Kushner & Lin Yang & Bi-Xing Chen & Alexander Kushnir & Katerina Dangas & Steven P, 2020. "Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics," Nature, Nature, vol. 577(7792), pages 695-700, January.
    Full references (including those not matched with items on IDEAS)

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