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Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018

Author

Listed:
  • Juan Yang

    (Ministry of Education)

  • Qiaohong Liao

    (Ministry of Education
    Chinese Center for Disease Control and Prevention)

  • Kaiwei Luo

    (Hunan Provincial Center for Disease Control and Prevention (Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences))

  • Fengfeng Liu

    (Chinese Center for Disease Control and Prevention)

  • Yonghong Zhou

    (Ministry of Education)

  • Gang Zou

    (Chinese Academy of Sciences)

  • Wei Huang

    (Hunan Provincial Center for Disease Control and Prevention (Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences))

  • Shuanbao Yu

    (Chinese Center for Disease Control and Prevention)

  • Xianglin Wei

    (Ministry of Education)

  • Jiaxin Zhou

    (Ministry of Education)

  • Bingbing Dai

    (Anhua County Center for Disease Control and Prevention)

  • Qi Qiu

    (Ministry of Education)

  • Ralf Altmeyer

    (Chinese Academy of Sciences
    Medusa Therapeutics Limited)

  • Hongan Hu

    (Anhua County Center for Disease Control and Prevention)

  • Juliette Paireau

    (Université Paris Cité, UMR2000, CNRS
    Santé publique France)

  • Li Luo

    (Chinese Center for Disease Control and Prevention)

  • Lidong Gao

    (Hunan Provincial Center for Disease Control and Prevention (Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences))

  • Birgit Nikolay

    (Université Paris Cité, UMR2000, CNRS)

  • Shixiong Hu

    (Hunan Provincial Center for Disease Control and Prevention (Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences))

  • Weijia Xing

    (Chinese Center for Disease Control and Prevention
    Shandong First Medical University & Shandong Academy of Medical Sciences)

  • Peng Wu

    (The University of Hong Kong, Hong Kong Special Administrative Region)

  • H. Rogier Doorn

    (Hospital for Tropical Diseases
    University of Oxford)

  • Peter W. Horby

    (University of Oxford)

  • Peter Simmonds

    (Hospital for Tropical Diseases)

  • Gabriel M. Leung

    (The University of Hong Kong, Hong Kong Special Administrative Region)

  • Benjamin J. Cowling

    (The University of Hong Kong, Hong Kong Special Administrative Region)

  • Simon Cauchemez

    (Université Paris Cité, UMR2000, CNRS)

  • Hongjie Yu

    (Ministry of Education)

Abstract

Enterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the introduction of the EV-A71 vaccine into the National Immunization Programme, we investigated the seroepidemiological characteristics of EV-A71 in two prospective cohorts of children in southern China conducted between 2013 and 2018. Our results show that maternal antibody titres declined rapidly in neonates, with over half becoming susceptible to EV-A71 at 1 month of age. Between 6 months and 2 years of age, over 80% of study participants were susceptible, while one third remained susceptible at 5 years old. The highest incidence of EV-A71 infections was observed in children aged 5-6 months. Our findings support EV-A71 vaccination before 6 months for birth cohorts in southern China, potentially with a one-time catch-up vaccination for children 6 months-5 years old. More regionally representative longitudinal seroepidemiological studies are needed to further validate these findings.

Suggested Citation

  • Juan Yang & Qiaohong Liao & Kaiwei Luo & Fengfeng Liu & Yonghong Zhou & Gang Zou & Wei Huang & Shuanbao Yu & Xianglin Wei & Jiaxin Zhou & Bingbing Dai & Qi Qiu & Ralf Altmeyer & Hongan Hu & Juliette P, 2022. "Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34992-1
    DOI: 10.1038/s41467-022-34992-1
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    Cited by:

    1. Rachel E. Baker & Wenchang Yang & Gabriel A. Vecchi & Saki Takahashi, 2024. "Increasing intensity of enterovirus outbreaks projected with climate change," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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