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Third primary SARS-CoV-2 mRNA vaccines enhance antibody responses in most patients with haematological malignancies

Author

Listed:
  • Lucy B. Cook

    (Imperial College London
    Imperial College Healthcare NHS Trust)

  • Gillian O’Dell

    (Imperial College Healthcare NHS Trust)

  • Eleni Vourvou

    (Imperial College Healthcare NHS Trust)

  • Renuka Palanicawandar

    (Imperial College Healthcare NHS Trust)

  • Sasha Marks

    (Imperial College Healthcare NHS Trust)

  • Dragana Milojkovic

    (Imperial College London
    Imperial College Healthcare NHS Trust)

  • Jane F. Apperley

    (Imperial College London
    Imperial College Healthcare NHS Trust)

  • Sandra Loaiza

    (Imperial College Healthcare NHS Trust)

  • Simone Claudiani

    (Imperial College Healthcare NHS Trust)

  • Marco Bua

    (Imperial College Healthcare NHS Trust)

  • Catherine Hockings

    (Imperial College Healthcare NHS Trust)

  • Donald Macdonald

    (Imperial College London
    Imperial College Healthcare NHS Trust)

  • Aris Chaidos

    (Imperial College London
    Imperial College Healthcare NHS Trust)

  • Jiri Pavlu

    (Imperial College Healthcare NHS Trust)

  • Nichola Cooper

    (Imperial College London
    Imperial College Healthcare NHS Trust)

  • Sarah Fidler

    (Imperial College London)

  • Paul Randell

    (North West London Pathology)

  • Andrew J. Innes

    (Imperial College London
    Imperial College Healthcare NHS Trust)

Abstract

SARS-CoV-2 infection, and resulting disease, COVID-19, has a high mortality amongst patients with haematological malignancies. Global vaccine rollouts have reduced hospitalisations and deaths, but vaccine efficacy in patients with haematological malignancies is known to be reduced. The UK-strategy offered a third, mRNA-based, vaccine as an extension to the primary course in these patients. The MARCH database is a retrospective observational study of serological responses in patients with blood disorders. Here we present data on 381 patients with haematological malignancies. By comparison with healthy controls, we report suboptimal responses following two primary vaccines, with significantly enhanced responses following the third primary dose. These responses however are heterogeneous and determined by haematological malignancy sub-type and therapy. We identify a group of patients with continued suboptimal vaccine responses who may benefit from additional doses, prophylactic extended half-life neutralising monoclonal therapies (nMAB) or prompt nMAB treatment in the event of SARS-CoV-2 infection.

Suggested Citation

  • Lucy B. Cook & Gillian O’Dell & Eleni Vourvou & Renuka Palanicawandar & Sasha Marks & Dragana Milojkovic & Jane F. Apperley & Sandra Loaiza & Simone Claudiani & Marco Bua & Catherine Hockings & Donald, 2022. "Third primary SARS-CoV-2 mRNA vaccines enhance antibody responses in most patients with haematological malignancies," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34657-z
    DOI: 10.1038/s41467-022-34657-z
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    References listed on IDEAS

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    1. Elizabeth J. Williamson & Alex J. Walker & Krishnan Bhaskaran & Seb Bacon & Chris Bates & Caroline E. Morton & Helen J. Curtis & Amir Mehrkar & David Evans & Peter Inglesby & Jonathan Cockburn & Helen, 2020. "Factors associated with COVID-19-related death using OpenSAFELY," Nature, Nature, vol. 584(7821), pages 430-436, August.
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