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Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer

Author

Listed:
  • Juan-Juan Li

    (Nankai University)

  • Yuqing Hu

    (Nankai University)

  • Bing Hu

    (Hebei University)

  • Wenbo Wang

    (Nankai University)

  • Haiqi Xu

    (Nankai University)

  • Xin-Yue Hu

    (Nankai University)

  • Fei Ding

    (Nankai University)

  • Hua-Bin Li

    (Nankai University)

  • Ke-Rang Wang

    (Hebei University)

  • Xinge Zhang

    (Nankai University)

  • Dong-Sheng Guo

    (Nankai University)

Abstract

Diabetic wound is one of the most intractable chronic wounds that is prone to bacterial infection. Hypoxia is an important feature in its microenvironment. However, it is challenging for antimicrobial therapy to directly apply the existing hypoxia-responsive drug delivery systems due to the active targeting deficiency and the biofilm obstacle. Herein, we customizes a hypoxia-responsive carrier, lactose-modified azocalix[4]arene (LacAC4A) with the ability to actively target and inhibit biofilm. By loading ciprofloxacin (Cip), the resultant supramolecular nanoformulation Cip@LacAC4A demonstrates enhanced antibacterial efficacy resulting from both the increased drug accumulation and the controlled release at the site of infection. When applied on diabetic wounds together with multidrug-resistant Pseudomonas aeruginosa infection in vivo, Cip@LacAC4A induces definitely less inflammatory infiltration than free Cip, which translates into high wound healing performance. Importantly, such design principle provides a direction for developing antimicrobial drug delivery systems.

Suggested Citation

  • Juan-Juan Li & Yuqing Hu & Bing Hu & Wenbo Wang & Haiqi Xu & Xin-Yue Hu & Fei Ding & Hua-Bin Li & Ke-Rang Wang & Xinge Zhang & Dong-Sheng Guo, 2022. "Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33920-7
    DOI: 10.1038/s41467-022-33920-7
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    Cited by:

    1. Jiahao Zhuang & Guobin Qi & Yecheng Feng & Min Wu & Hang Zhang & Dandan Wang & Xianhe Zhang & Kok Chan Chong & Bowen Li & Shitai Liu & Jianwu Tian & Yi Shan & Duo Mao & Bin Liu, 2024. "Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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