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Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern

Author

Listed:
  • Danique M. H. Rijswijck

    (University of Utrecht
    Netherlands Proteomic Center)

  • Albert Bondt

    (University of Utrecht
    Netherlands Proteomic Center)

  • Max Hoek

    (University of Utrecht
    Netherlands Proteomic Center)

  • Karlijn Straten

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity
    Vrije Universiteit Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Tom G. Caniels

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Meliawati Poniman

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Dirk Eggink

    (National Institute for Public Health and the Environment, RIVM)

  • Chantal Reusken

    (National Institute for Public Health and the Environment, RIVM)

  • Godelieve J. Bree

    (Vrije Universiteit Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Rogier W. Sanders

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Marit J. Gils

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Albert J. R. Heck

    (University of Utrecht
    Netherlands Proteomic Center)

Abstract

Existing assays to measure antibody cross-reactivity against different SARS-CoV-2 spike (S) protein variants lack the discriminatory power to provide insights at the level of individual clones. Using a mass spectrometry-based approach we are able to monitor individual donors’ IgG1 clonal responses following a SARS-CoV-2 infection. We monitor the plasma clonal IgG1 profiles of 8 donors who had experienced an infection by either the wild type Wuhan Hu-1 virus or one of 3 VOCs (Alpha, Beta and Gamma). In these donors we chart the full plasma IgG1 repertoires as well as the IgG1 repertoires targeting the SARS-CoV-2 spike protein trimer VOC antigens. The plasma of each donor contains numerous anti-spike IgG1 antibodies, accounting for

Suggested Citation

  • Danique M. H. Rijswijck & Albert Bondt & Max Hoek & Karlijn Straten & Tom G. Caniels & Meliawati Poniman & Dirk Eggink & Chantal Reusken & Godelieve J. Bree & Rogier W. Sanders & Marit J. Gils & Alber, 2022. "Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33899-1
    DOI: 10.1038/s41467-022-33899-1
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    1. Bin Ju & Qi Zhang & Jiwan Ge & Ruoke Wang & Jing Sun & Xiangyang Ge & Jiazhen Yu & Sisi Shan & Bing Zhou & Shuo Song & Xian Tang & Jinfang Yu & Jun Lan & Jing Yuan & Haiyan Wang & Juanjuan Zhao & Shuy, 2020. "Human neutralizing antibodies elicited by SARS-CoV-2 infection," Nature, Nature, vol. 584(7819), pages 115-119, August.
    2. Michiel Waterbeemd & Sem Tamara & Kyle L. Fort & Eugen Damoc & Vojtech Franc & Philipp Bieri & Martin Itten & Alexander Makarov & Nenad Ban & Albert J. R. Heck, 2018. "Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
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