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Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells

Author

Listed:
  • Baju Joy

    (Massachusetts Institute of Technology)

  • Yubin Cai

    (Massachusetts Institute of Technology)

  • David C. Bono

    (Massachusetts Institute of Technology)

  • Deblina Sarkar

    (Massachusetts Institute of Technology)

Abstract

An intracellular antenna can open up new horizons for fundamental and applied biology. Here, we introduce the Cell Rover, a magnetostrictive antenna which can operate wirelessly inside a living cell and is compatible with 3D biological systems. It is sub-mm in size, acoustically actuated by an AC magnetic field and resonantly operated at low MHz frequencies, which is ideal for living systems. We developed an injection scheme involving non-uniform magnetic fields for intracellular injection of the Cell Rovers and demonstrated their operation in fully opaque, stage VI Xenopus oocytes, for which real-time imaging with conventional technologies is challenging. We also show that they provide a pathway for multiplexing applications to individually address multiple cells or to tune to more than one antenna within the same cell for versatile functionalities. This technology forms the foundation stone that can enable the integration of future capabilities such as smart sensing, modulation as well as energy harvesting to power in-cell nanoelectronic computing and can potentially bring the prowess of information technology inside a living cell. This could lead to unprecedented opportunities for fundamental understanding of biology as well as diagnostics and therapeutics.

Suggested Citation

  • Baju Joy & Yubin Cai & David C. Bono & Deblina Sarkar, 2022. "Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32862-4
    DOI: 10.1038/s41467-022-32862-4
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    References listed on IDEAS

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    1. Tianxiang Nan & Hwaider Lin & Yuan Gao & Alexei Matyushov & Guoliang Yu & Huaihao Chen & Neville Sun & Shengjun Wei & Zhiguang Wang & Menghui Li & Xinjun Wang & Amine Belkessam & Rongdi Guo & Brian Ch, 2017. "Acoustically actuated ultra-compact NEMS magnetoelectric antennas," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    2. Andrijana Kriz & Katharina Schmid & Nadia Baumgartner & Urs Ziegler & Imre Berger & Kurt Ballmer-Hofer & Philipp Berger, 2010. "A plasmid-based multigene expression system for mammalian cells," Nature Communications, Nature, vol. 1(1), pages 1-6, December.
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