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Control cell migration by engineering integrin ligand assembly

Author

Listed:
  • Xunwu Hu

    (Active Soft Matter Group, CAS Songshan Lake Materials Laboratory
    Okinawa Institute of Science and Technology Graduate University)

  • Sona Rani Roy

    (Okinawa Institute of Science and Technology Graduate University)

  • Chengzhi Jin

    (Okinawa Institute of Science and Technology Graduate University
    Guangzhou Medical University)

  • Guanying Li

    (Okinawa Institute of Science and Technology Graduate University
    Xi’an Jiaotong University)

  • Qizheng Zhang

    (Okinawa Institute of Science and Technology Graduate University
    City University of Hong Kong)

  • Natsuko Asano

    (SM Application Group, JEOL Ltd.)

  • Shunsuke Asahina

    (SM Application Group, JEOL Ltd.)

  • Tomoko Kajiwara

    (Kyushu University)

  • Atsushi Takahara

    (Kyushu University)

  • Bolu Feng

    (Okinawa Institute of Science and Technology Graduate University)

  • Kazuhiro Aoki

    (Division of Quantitative Biology, National Institute for Basic Biology, National Institute of Natural Sciences
    Quantitative Biology Research Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences
    SOKENDAI (The Graduate University for Advanced Studies))

  • Chenjie Xu

    (City University of Hong Kong)

  • Ye Zhang

    (Active Soft Matter Group, CAS Songshan Lake Materials Laboratory
    Okinawa Institute of Science and Technology Graduate University)

Abstract

Advances in mechanistic understanding of integrin-mediated adhesion highlight the importance of precise control of ligand presentation in directing cell migration. Top-down nanopatterning limited the spatial presentation to sub-micron placing restrictions on both fundamental study and biomedical applications. To break the constraint, here we propose a bottom-up nanofabrication strategy to enhance the spatial resolution to the molecular level using simple formulation that is applicable as treatment agent. Via self-assembly and co-assembly, precise control of ligand presentation is succeeded by varying the proportions of assembling ligand and nonfunctional peptide. Assembled nanofilaments fulfill multi-functions exerting enhancement to suppression effect on cell migration with tunable amplitudes. Self-assembled nanofilaments possessing by far the highest ligand density prevent integrin/actin disassembly at cell rear, which expands the perspective of ligand-density-dependent-modulation, revealing valuable inputs to therapeutic innovations in tumor metastasis.

Suggested Citation

  • Xunwu Hu & Sona Rani Roy & Chengzhi Jin & Guanying Li & Qizheng Zhang & Natsuko Asano & Shunsuke Asahina & Tomoko Kajiwara & Atsushi Takahara & Bolu Feng & Kazuhiro Aoki & Chenjie Xu & Ye Zhang, 2022. "Control cell migration by engineering integrin ligand assembly," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32686-2
    DOI: 10.1038/s41467-022-32686-2
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    References listed on IDEAS

    as
    1. Amy Y. Clark & Karen E. Martin & José R. García & Christopher T. Johnson & Hannah S. Theriault & Woojin M. Han & Dennis W. Zhou & Edward A. Botchwey & Andrés J. García, 2020. "Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    2. Takao Arimori & Naoyuki Miyazaki & Emiko Mihara & Mamoru Takizawa & Yukimasa Taniguchi & Carlos Cabañas & Kiyotoshi Sekiguchi & Junichi Takagi, 2021. "Structural mechanism of laminin recognition by integrin," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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