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On maternity and the stronger immune response in women

Author

Listed:
  • Evan Mitchell

    (Western University)

  • Andrea L. Graham

    (Princeton University)

  • Francisco Úbeda

    (University of London Egham)

  • Geoff Wild

    (Western University)

Abstract

Medical research reports that women often exhibit stronger immune responses than men, while pathogens tend to be more virulent in men. Current explanations cannot account for this pattern, creating an obstacle for our understanding of infectious-disease outcomes and the incidence of autoimmune diseases. We offer an alternative explanation that relies on a fundamental difference between the sexes: maternity and the opportunities it creates for transmission of pathogens from mother to child (vertical transmission). Our explanation relies on a mathematical model of the co-evolution of host immunocompetence and pathogen virulence. Here, we show that when there is sufficient vertical transmission co-evolution leads women to defend strongly against temperate pathogens and men to defend weakly against aggressive pathogens, in keeping with medical observations. From a more applied perspective, we argue that limiting vertical transmission of infections would alleviate the disproportionate incidence of autoimmune diseases in women over evolutionary time.

Suggested Citation

  • Evan Mitchell & Andrea L. Graham & Francisco Úbeda & Geoff Wild, 2022. "On maternity and the stronger immune response in women," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32569-6
    DOI: 10.1038/s41467-022-32569-6
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    References listed on IDEAS

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    1. Alison M. Kim & Candace M. Tingen & Teresa K. Woodruff, 2010. "Sex bias in trials and treatment must end," Nature, Nature, vol. 465(7299), pages 688-689, June.
    2. Shani Talia Gal-Oz & Barbara Maier & Hideyuki Yoshida & Kumba Seddu & Nitzan Elbaz & Charles Czysz & Or Zuk & Barbara E. Stranger & Hadas Ner-Gaon & Tal Shay, 2019. "ImmGen report: sexual dimorphism in the immune system transcriptome," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    3. C. Jessica E. Metcalf & Andrea L. Graham, 2018. "Schedule and magnitude of reproductive investment under immune trade-offs explains sex differences in immunity," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    4. Fabio Dercole & Sergio Rinaldi, 2008. "Introduction to Analysis of Evolutionary Processes: The Adaptive Dynamics Approach and Its Applications," Introductory Chapters, in: Analysis of Evolutionary Processes: The Adaptive Dynamics Approach and Its Applications, Princeton University Press.
    5. Andrew M. Stoehr & Hanna Kokko, 2006. "Sexual dimorphism in immunocompetence: what does life-history theory predict?," Behavioral Ecology, International Society for Behavioral Ecology, vol. 17(5), pages 751-756, September.
    6. U. Dieckmann & R. Law, 1996. "The Dynamical Theory of Coevolution: A Derivation from Stochastic Ecological Processes," Working Papers wp96001, International Institute for Applied Systems Analysis.
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