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ImmGen report: sexual dimorphism in the immune system transcriptome

Author

Listed:
  • Shani Talia Gal-Oz

    (Ben-Gurion University of the Negev)

  • Barbara Maier

    (The Precision Immunology Institute & Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai)

  • Hideyuki Yoshida

    (Harvard Medical School
    RIKEN Center for Integrative Medical Sciences)

  • Kumba Seddu

    (Harvard Medical School)

  • Nitzan Elbaz

    (Ben-Gurion University of the Negev)

  • Charles Czysz

    (University of Chicago)

  • Or Zuk

    (The Hebrew University of Jerusalem)

  • Barbara E. Stranger

    (University of Chicago
    Feinberg School of Medicine, Northwestern University)

  • Hadas Ner-Gaon

    (Ben-Gurion University of the Negev)

  • Tal Shay

    (Ben-Gurion University of the Negev)

Abstract

Sexual dimorphism in the mammalian immune system is manifested as more frequent and severe infectious diseases in males and, on the other hand, higher rates of autoimmune disease in females, yet insights underlying those differences are still lacking. Here we characterize sex differences in the immune system by RNA and ATAC sequence profiling of untreated and interferon-induced immune cell types in male and female mice. We detect very few differentially expressed genes between male and female immune cells except in macrophages from three different tissues. Accordingly, very few genomic regions display differences in accessibility between sexes. Transcriptional sexual dimorphism in macrophages is mediated by genes of innate immune pathways, and increases after interferon stimulation. Thus, the stronger immune response of females may be due to more activated innate immune pathways prior to pathogen invasion.

Suggested Citation

  • Shani Talia Gal-Oz & Barbara Maier & Hideyuki Yoshida & Kumba Seddu & Nitzan Elbaz & Charles Czysz & Or Zuk & Barbara E. Stranger & Hadas Ner-Gaon & Tal Shay, 2019. "ImmGen report: sexual dimorphism in the immune system transcriptome," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12348-6
    DOI: 10.1038/s41467-019-12348-6
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    Cited by:

    1. Evan Mitchell & Andrea L. Graham & Francisco Úbeda & Geoff Wild, 2022. "On maternity and the stronger immune response in women," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Nicolaj S. Hackert & Felix A. Radtke & Tarik Exner & Hanns-Martin Lorenz & Carsten Müller-Tidow & Peter A. Nigrovic & Guido Wabnitz & Ricardo Grieshaber-Bouyer, 2023. "Human and mouse neutrophils share core transcriptional programs in both homeostatic and inflamed contexts," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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