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Vaccine effectiveness of CoronaVac against COVID-19 among children in Brazil during the Omicron period

Author

Listed:
  • Pilar T. V. Florentino

    (Oswaldo Cruz Foundation (Fiocruz)
    University of São Paulo)

  • Flávia J. O. Alves

    (Oswaldo Cruz Foundation (Fiocruz))

  • Thiago Cerqueira-Silva

    (Oswaldo Cruz Foundation (Fiocruz)
    Federal University of Bahia)

  • Vinicius de Araújo Oliveira

    (Oswaldo Cruz Foundation (Fiocruz)
    Federal University of Bahia)

  • Juracy B. S. Júnior

    (Federal University of Bahia)

  • Adelson G. Jantsch

    (Oswaldo Cruz Foundation (Fiocruz))

  • Gerson O. Penna

    (University of Brasília, Fiocruz School of Government)

  • Viviane Boaventura

    (Oswaldo Cruz Foundation (Fiocruz)
    Federal University of Bahia)

  • Guilherme L. Werneck

    (State University of Rio de Janeiro
    Federal University of Rio de Janeiro)

  • Laura C. Rodrigues

    (London School of Hygiene and Tropical Medicine)

  • Neil Pearce

    (London School of Hygiene and Tropical Medicine)

  • Manoel Barral-Netto

    (Oswaldo Cruz Foundation (Fiocruz)
    Federal University of Bahia)

  • Mauricio L. Barreto

    (Oswaldo Cruz Foundation (Fiocruz))

  • Enny S. Paixão

    (London School of Hygiene and Tropical Medicine)

Abstract

Although severe COVID-19 in children is rare, they may develop multisystem inflammatory syndrome, long-COVID and downstream effects of COVID-19, including social isolation and disruption of education. Data on the effectiveness of the CoronaVac vaccine is scarce during the Omicron period. In Brazil, children between 6 to 11 years are eligible to receive the CoronaVac vaccine. We conducted a test-negative design to estimate vaccine effectiveness using 197,958 tests from January 21, 2022, to April 15, 2022, during the Omicron dominant period in Brazil among children aged 6 to 11 years. The estimated vaccine effectiveness for symptomatic infection was 39.8% (95% CI 33.7–45.4) at ≥14 days post-second dose. For hospital admission vaccine effectiveness was 59.2% (95% CI 11.3–84.5) at ≥14 days. Two doses of CoronaVac in children during the Omicron period showed low levels of protection against symptomatic infection, and modest levels against severe illness.

Suggested Citation

  • Pilar T. V. Florentino & Flávia J. O. Alves & Thiago Cerqueira-Silva & Vinicius de Araújo Oliveira & Juracy B. S. Júnior & Adelson G. Jantsch & Gerson O. Penna & Viviane Boaventura & Guilherme L. Wern, 2022. "Vaccine effectiveness of CoronaVac against COVID-19 among children in Brazil during the Omicron period," Nature Communications, Nature, vol. 13(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32524-5
    DOI: 10.1038/s41467-022-32524-5
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    References listed on IDEAS

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    1. van Buuren, Stef & Groothuis-Oudshoorn, Karin, 2011. "mice: Multivariate Imputation by Chained Equations in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 45(i03).
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