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Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy

Author

Listed:
  • Mary Prahl

    (University of California
    University of California)

  • Yarden Golan

    (University of California)

  • Arianna G. Cassidy

    (University of California San Francisco)

  • Yusuke Matsui

    (Gladstone Center for HIV Cure Research, Gladstone Institute)

  • Lin Li

    (University of California San Francisco
    University of California San Francisco)

  • Bonny Alvarenga

    (University of California)

  • Hao Chen

    (University of California San Francisco)

  • Unurzul Jigmeddagva

    (University of California San Francisco)

  • Christine Y. Lin

    (University of California San Francisco)

  • Veronica J. Gonzalez

    (University of California San Francisco)

  • Megan A. Chidboy

    (University of California San Francisco
    University of California San Francisco)

  • Lakshmi Warrier

    (University of California)

  • Sirirak Buarpung

    (University of California San Francisco
    University of California San Francisco)

  • Amy P. Murtha

    (University of California San Francisco)

  • Valerie J. Flaherman

    (University of California)

  • Warner C. Greene

    (Gladstone Center for HIV Cure Research, Gladstone Institute
    University of California
    University of California)

  • Alan H. B. Wu

    (University of California)

  • Kara L. Lynch

    (University of California)

  • Jayant Rajan

    (University of California)

  • Stephanie L. Gaw

    (University of California San Francisco
    University of California San Francisco)

Abstract

Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy.

Suggested Citation

  • Mary Prahl & Yarden Golan & Arianna G. Cassidy & Yusuke Matsui & Lin Li & Bonny Alvarenga & Hao Chen & Unurzul Jigmeddagva & Christine Y. Lin & Veronica J. Gonzalez & Megan A. Chidboy & Lakshmi Warrie, 2022. "Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32188-1
    DOI: 10.1038/s41467-022-32188-1
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    References listed on IDEAS

    as
    1. Claudio Fenizia & Mara Biasin & Irene Cetin & Patrizia Vergani & Davide Mileto & Arsenio Spinillo & Maria Rita Gismondo & Francesca Perotti & Clelia Callegari & Alessandro Mancon & Selene Cammarata & , 2020. "Analysis of SARS-CoV-2 vertical transmission during pregnancy," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

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