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Analysis of SARS-CoV-2 vertical transmission during pregnancy

Author

Listed:
  • Claudio Fenizia

    (University of Milan)

  • Mara Biasin

    (University of Milan)

  • Irene Cetin

    (Department of Woman, Mother and Neonate Buzzi Children’s Hospital, ASST Fatebenefratelli‐Sacco, Department of Biomedical and Clinical Sciences)

  • Patrizia Vergani

    (Fondazione MBBM, San Gerardo Hospital, University of Milan-Bicocca)

  • Davide Mileto

    (Clinical Microbiology, Virology and Bio-emergence Diagnosis, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences, University of Milan)

  • Arsenio Spinillo

    (Department of Obstetrics and Gynecology, IRCCS Fondazione Policlinico San Matteo, University of Pavia)

  • Maria Rita Gismondo

    (Clinical Microbiology, Virology and Bio-emergence Diagnosis, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences, University of Milan)

  • Francesca Perotti

    (IRCCS Fondazione Policlinico San Matteo)

  • Clelia Callegari

    (Fondazione MBBM, San Gerardo Hospital, University of Milan-Bicocca)

  • Alessandro Mancon

    (Clinical Microbiology, Virology and Bio-emergence Diagnosis, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences, University of Milan)

  • Selene Cammarata

    (Unit of Obstetrics and Gynecology, ASST Fatebenefratelli-Sacco, Department of Biological and Clinical Sciences, University of Milan)

  • Ilaria Beretta

    (San Gerardo Hospital, ASST Monza)

  • Manuela Nebuloni

    (Pathology Unit, ASST Fatebenfretalli-Sacco, Department of Biological and Clinical Sciences, University of Milan)

  • Daria Trabattoni

    (University of Milan)

  • Mario Clerici

    (University of Milan
    IRCCS Fondazione don Carlo Gnocchi)

  • Valeria Savasi

    (Unit of Obstetrics and Gynecology, ASST Fatebenefratelli-Sacco, Department of Biological and Clinical Sciences, University of Milan)

Abstract

The impact of SARS-CoV-2 infection during gestation remains unclear. Here, we analyse the viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal and umbilical cord plasma, placenta and umbilical cord biopsies, amniotic fluids and milk from 31 mothers with SARS-CoV-2 infection. In addition, we also test specific anti-SARS-CoV-2 antibodies and expression of genes involved in inflammatory responses in placentas, and in maternal and umbilical cord plasma. We detect SARS-CoV-2 genome in one umbilical cord blood and in two at-term placentas, in one vaginal mucosa and in one milk specimen. Furthermore, we report the presence of specific anti-SARS-CoV-2 IgM and IgG antibodies in one umbilical cord blood and in one milk specimen. Finally, in the three documented cases of vertical transmission, SARS-CoV-2 infection was accompanied by a strong inflammatory response. Together, these data support the hypothesis that in utero SARS-CoV-2 vertical transmission, while low, is possible. These results might help defining proper obstetric management of COVID-19 pregnant women, or putative indications for mode and timing of delivery.

Suggested Citation

  • Claudio Fenizia & Mara Biasin & Irene Cetin & Patrizia Vergani & Davide Mileto & Arsenio Spinillo & Maria Rita Gismondo & Francesca Perotti & Clelia Callegari & Alessandro Mancon & Selene Cammarata & , 2020. "Analysis of SARS-CoV-2 vertical transmission during pregnancy," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18933-4
    DOI: 10.1038/s41467-020-18933-4
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    Cited by:

    1. Clara Calvert & Jade Carruthers & Cheryl Denny & Jack Donaghy & Lisa E. M. Hopcroft & Leanne Hopkins & Anna Goulding & Laura Lindsay & Terry McLaughlin & Emily Moore & Bob Taylor & Maria Loane & Helen, 2023. "A population-based matched cohort study of major congenital anomalies following COVID-19 vaccination and SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Mary Prahl & Yarden Golan & Arianna G. Cassidy & Yusuke Matsui & Lin Li & Bonny Alvarenga & Hao Chen & Unurzul Jigmeddagva & Christine Y. Lin & Veronica J. Gonzalez & Megan A. Chidboy & Lakshmi Warrie, 2022. "Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Peter Radvak & Hyung-Joon Kwon & Martina Kosikova & Uriel Ortega-Rodriguez & Ruoxuan Xiang & Je-Nie Phue & Rong-Fong Shen & James Rozzelle & Neeraj Kapoor & Taylor Rabara & Jeff Fairman & Hang Xie, 2021. "SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Olivia M. Man & Tamiris Azamor & Mary Catherine Cambou & Trevon L. Fuller & Tara Kerin & Sophia G. Paiola & Jessica S. Cranston & Thalia Mok & Rashmi Rao & Weiqiang Chen & Jae U. Jung & Viviana Fajard, 2024. "Respiratory distress in SARS-CoV-2 exposed uninfected neonates followed in the COVID Outcomes in Mother-Infant Pairs (COMP) Study," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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