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Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

Author

Listed:
  • André A. Weber

    (University of California, San Diego)

  • Xiaojing Yang

    (University of California, San Diego)

  • Elvira Mennillo

    (University of California, San Diego)

  • Jeffrey Ding

    (University of California, San Diego)

  • Jeramie D. Watrous

    (University of California, San Diego)

  • Mohit Jain

    (University of California, San Diego)

  • Shujuan Chen

    (University of California, San Diego)

  • Michael Karin

    (University of California, San Diego)

  • Robert H. Tukey

    (University of California, San Diego)

Abstract

Here we show that Triclosan (TCS), a high-volume antimicrobial additive that has been detected in human breastmilk, can be efficiently transferred by lactation to newborn mice, causing significant fatty liver (FL) during the suckling period. These findings are relevant since pediatric non-alcoholic fatty liver disease (NAFLD) is escalating in the United States, with a limited mechanistic understanding. Lactational delivery stimulated hepatosteatosis, triglyceride accumulation, endoplasmic reticulum (ER) stress, signs of inflammation, and liver fibrosis. De novo lipogenesis (DNL) induced by lactational TCS exposure is shown to be mediated in a PERK-eIF2α-ATF4-PPARα cascade. The administration of obeticholic acid (OCA), a potent FXR agonist, as well as activation of intestinal mucosal-regenerative gp130 signaling, led to reduced liver ATF4 expression, PPARα signaling, and DNL when neonates were exposed to TCS. It is yet to be investigated but mother to child transmission of TCS or similar toxicants may underlie the recent increases in pediatric NAFLD.

Suggested Citation

  • André A. Weber & Xiaojing Yang & Elvira Mennillo & Jeffrey Ding & Jeramie D. Watrous & Mohit Jain & Shujuan Chen & Michael Karin & Robert H. Tukey, 2022. "Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31947-4
    DOI: 10.1038/s41467-022-31947-4
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    1. Pere Puigserver & James Rhee & Jerry Donovan & Christopher J. Walkey & J. Cliff Yoon & Francesco Oriente & Yukari Kitamura & Jennifer Altomonte & Hengjiang Dong & Domenico Accili & Bruce M. Spiegelman, 2003. "Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction," Nature, Nature, vol. 423(6939), pages 550-555, May.
    2. Jianan Zhang & Morgan E. Walker & Katherine Z. Sanidad & Hongna Zhang & Yanshan Liang & Ermin Zhao & Katherine Chacon-Vargas & Vladimir Yeliseyev & Julie Parsonnet & Thomas D. Haggerty & Guangqiang Wa, 2022. "Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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