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Regulation of AUXIN RESPONSE FACTOR condensation and nucleo-cytoplasmic partitioning

Author

Listed:
  • Hongwei Jing

    (Duke University
    Washington University
    Washington University)

  • David A. Korasick

    (Washington University)

  • Ryan J. Emenecker

    (Washington University
    Washington University
    Washington University)

  • Nicholas Morffy

    (Duke University
    Washington University
    Washington University)

  • Edward G. Wilkinson

    (Duke University
    Washington University
    Washington University)

  • Samantha K. Powers

    (Washington University)

  • Lucia C. Strader

    (Duke University
    Washington University
    Washington University)

Abstract

Auxin critically regulates plant growth and development. Auxin-driven transcriptional responses are mediated through the AUXIN RESPONSE FACTOR (ARF) family of transcription factors. ARF protein condensation attenuates ARF activity, resulting in dramatic shifts in the auxin transcriptional landscape. Here, we perform a forward genetics screen for ARF hypercondensation, identifying an F-box protein, which we named AUXIN RESPONSE FACTOR F-BOX1 (AFF1). Functional characterization of SCFAFF1 revealed that this E3 ubiquitin ligase directly interacts with ARF19 and ARF7 to regulate their accumulation, condensation, and nucleo-cytoplasmic partitioning. Mutants defective in AFF1 display attenuated auxin responsiveness, and developmental defects, suggesting that SCFAFF1 -mediated regulation of ARF protein drives aspects of auxin response and plant development.

Suggested Citation

  • Hongwei Jing & David A. Korasick & Ryan J. Emenecker & Nicholas Morffy & Edward G. Wilkinson & Samantha K. Powers & Lucia C. Strader, 2022. "Regulation of AUXIN RESPONSE FACTOR condensation and nucleo-cytoplasmic partitioning," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31628-2
    DOI: 10.1038/s41467-022-31628-2
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    References listed on IDEAS

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    1. Hongwei Jing & Xiaolu Yang & Jian Zhang & Xuehui Liu & Huakun Zheng & Guojun Dong & Jinqiang Nian & Jian Feng & Bin Xia & Qian Qian & Jiayang Li & Jianru Zuo, 2015. "Peptidyl-prolyl isomerization targets rice Aux/IAAs for proteasomal degradation during auxin signalling," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
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