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Dissociation between individual differences in self-reported pain intensity and underlying fMRI brain activation

Author

Listed:
  • M. E. Hoeppli

    (Pediatric Pain Research Center (PPRC), Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center)

  • H. Nahman-Averbuch

    (Pediatric Pain Research Center (PPRC), Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center
    Washington University School of Medicine)

  • W. A. Hinkle

    (Pediatric Pain Research Center (PPRC), Cincinnati Children’s Hospital Medical Center)

  • E. Leon

    (Pediatric Pain Research Center (PPRC), Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center)

  • J. Peugh

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati, College of Medicine)

  • M. Lopez-Sola

    (University of Barcelona)

  • C. D. King

    (Pediatric Pain Research Center (PPRC), Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center
    University of Cincinnati, College of Medicine)

  • K. R. Goldschneider

    (Pediatric Pain Research Center (PPRC), Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center)

  • R. C. Coghill

    (Pediatric Pain Research Center (PPRC), Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center
    University of Cincinnati, College of Medicine)

Abstract

Pain is an individual experience. Previous studies have highlighted changes in brain activation and morphology associated with within- and interindividual pain perception. In this study we sought to characterize brain mechanisms associated with between-individual differences in pain in a sample of healthy adolescent and adult participants (N = 101). Here we show that pain ratings varied widely across individuals and that individuals reported changes in pain evoked by small differences in stimulus intensity in a manner congruent with their pain sensitivity, further supporting the utility of subjective reporting as a measure of the true individual experience. Furthermore, brain activation related to interindividual differences in pain was not detected, despite clear sensitivity of the Blood Oxygenation Level-Dependent (BOLD) signal to small differences in noxious stimulus intensities within individuals. These findings suggest fMRI may not be a useful objective measure to infer reported pain intensity.

Suggested Citation

  • M. E. Hoeppli & H. Nahman-Averbuch & W. A. Hinkle & E. Leon & J. Peugh & M. Lopez-Sola & C. D. King & K. R. Goldschneider & R. C. Coghill, 2022. "Dissociation between individual differences in self-reported pain intensity and underlying fMRI brain activation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31039-3
    DOI: 10.1038/s41467-022-31039-3
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    References listed on IDEAS

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    1. Choong-Wan Woo & Mathieu Roy & Jason T Buhle & Tor D Wager, 2015. "Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain," PLOS Biology, Public Library of Science, vol. 13(1), pages 1-14, January.
    2. Choong-Wan Woo & Liane Schmidt & Anjali Krishnan & Marieke Jepma & Mathieu Roy & Martin A. Lindquist & Lauren Y. Atlas & Tor D. Wager, 2017. "Quantifying cerebral contributions to pain beyond nociception," Nature Communications, Nature, vol. 8(1), pages 1-14, April.
    3. Krieger, Nancy & Smith, Kevin & Naishadham, Deepa & Hartman, Cathy & Barbeau, Elizabeth M., 2005. "Experiences of discrimination: Validity and reliability of a self-report measure for population health research on racism and health," Social Science & Medicine, Elsevier, vol. 61(7), pages 1576-1596, October.
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    Cited by:

    1. Suhwan Gim & Dong Hee Lee & Sungwoo Lee & Choong-Wan Woo, 2024. "Interindividual differences in pain can be explained by fMRI, sociodemographic, and psychological factors," Nature Communications, Nature, vol. 15(1), pages 1-6, December.

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