IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30980-7.html
   My bibliography  Save this article

Fibrous hydrogels under biaxial confinement

Author

Listed:
  • Yang Li

    (University of Toronto
    University Medical Center Utrecht, Utrecht University)

  • Yunfeng Li

    (University of Toronto
    Jilin University)

  • Elisabeth Prince

    (University of Toronto
    Massachusetts Institute of Technology)

  • Jeffrey I. Weitz

    (Thrombosis and Atherosclerosis Research Institute
    McMaster University
    McMaster University)

  • Sergey Panyukov

    (P. N. Lebedev Physics Institute, Russian Academy of Sciences)

  • Arun Ramachandran

    (University of Toronto)

  • Michael Rubinstein

    (Duke University
    Duke University
    Duke University
    Duke University)

  • Eugenia Kumacheva

    (University of Toronto
    University of Toronto
    University of Toronto)

Abstract

Confinement of fibrous hydrogels in narrow capillaries is of great importance in biological and biomedical systems. Stretching and uniaxial compression of fibrous hydrogels have been extensively studied; however, their response to biaxial confinement in capillaries remains unexplored. Here, we show experimentally and theoretically that due to the asymmetry in the mechanical properties of the constituent filaments that are soft upon compression and stiff upon extension, filamentous gels respond to confinement in a qualitatively different manner than flexible-strand gels. Under strong confinement, fibrous gels exhibit a weak elongation and an asymptotic decrease to zero of their biaxial Poisson’s ratio, which results in strong gel densification and a weak flux of liquid through the gel. These results shed light on the resistance of strained occlusive clots to lysis with therapeutic agents and stimulate the development of effective endovascular plugs from gels with fibrous structures for stopping vascular bleeding or suppressing blood supply to tumors.

Suggested Citation

  • Yang Li & Yunfeng Li & Elisabeth Prince & Jeffrey I. Weitz & Sergey Panyukov & Arun Ramachandran & Michael Rubinstein & Eugenia Kumacheva, 2022. "Fibrous hydrogels under biaxial confinement," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30980-7
    DOI: 10.1038/s41467-022-30980-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30980-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30980-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Cornelis Storm & Jennifer J. Pastore & F. C. MacKintosh & T. C. Lubensky & Paul A. Janmey, 2005. "Nonlinear elasticity in biological gels," Nature, Nature, vol. 435(7039), pages 191-194, May.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hren, Robert & Vujanović, Annamaria & Van Fan, Yee & Klemeš, Jiří Jaromír & Krajnc, Damjan & Čuček, Lidija, 2023. "Hydrogen production, storage and transport for renewable energy and chemicals: An environmental footprint assessment," Renewable and Sustainable Energy Reviews, Elsevier, vol. 173(C).
    2. Cheng, Fangwei & Luo, Hongxi & Jenkins, Jesse D. & Larson, Eric D., 2023. "The value of low- and negative-carbon fuels in the transition to net-zero emission economies: Lifecycle greenhouse gas emissions and cost assessments across multiple fuel types," Applied Energy, Elsevier, vol. 331(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jason X. Liu & Mikko P. Haataja & Andrej Košmrlj & Sujit S. Datta & Craig B. Arnold & Rodney D. Priestley, 2023. "Liquid–liquid phase separation within fibrillar networks," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. M․, Hariprasad & Venkatapathi, Murugesan, 2021. "Semi-analytical solutions for eigenvalue problems of chains and periodic graphs," Applied Mathematics and Computation, Elsevier, vol. 411(C).
    3. Jiu-Tao Hang & Yu Kang & Guang-Kui Xu & Huajian Gao, 2021. "A hierarchical cellular structural model to unravel the universal power-law rheological behavior of living cells," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    4. Ashley L. Nord & Anaïs Biquet-Bisquert & Manouk Abkarian & Théo Pigaglio & Farida Seduk & Axel Magalon & Francesco Pedaci, 2022. "Dynamic stiffening of the flagellar hook," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    5. René F M van Oers & Elisabeth G Rens & Danielle J LaValley & Cynthia A Reinhart-King & Roeland M H Merks, 2014. "Mechanical Cell-Matrix Feedback Explains Pairwise and Collective Endothelial Cell Behavior In Vitro," PLOS Computational Biology, Public Library of Science, vol. 10(8), pages 1-14, August.
    6. Qingqiao Xie & Yuandi Zhuang & Gaojun Ye & Tiankuo Wang & Yi Cao & Lingxiang Jiang, 2021. "Astral hydrogels mimic tissue mechanics by aster-aster interpenetration," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    7. Jin Qian & Huajian Gao, 2010. "Soft Matrices Suppress Cooperative Behaviors among Receptor-Ligand Bonds in Cell Adhesion," PLOS ONE, Public Library of Science, vol. 5(8), pages 1-9, August.
    8. Xin Tang & Alireza Tofangchi & Sandeep V Anand & Taher A Saif, 2014. "A Novel Cell Traction Force Microscopy to Study Multi-Cellular System," PLOS Computational Biology, Public Library of Science, vol. 10(6), pages 1-15, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30980-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.