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Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces

Author

Listed:
  • Su Z. Hong

    (Johns Hopkins University)

  • Lukas Mesik

    (Johns Hopkins University)

  • Cooper D. Grossman

    (Johns Hopkins University)

  • Jeremiah Y. Cohen

    (Johns Hopkins University)

  • Boram Lee

    (University of California at Davis)

  • Daniel Severin

    (Johns Hopkins University)

  • Hey-Kyoung Lee

    (Johns Hopkins University
    Johns Hopkins University)

  • Johannes W. Hell

    (University of California at Davis)

  • Alfredo Kirkwood

    (Johns Hopkins University
    Johns Hopkins University)

Abstract

Reinforcement allows organisms to learn which stimuli predict subsequent biological relevance. Hebbian mechanisms of synaptic plasticity are insufficient to account for reinforced learning because neuromodulators signaling biological relevance are delayed with respect to the neural activity associated with the stimulus. A theoretical solution is the concept of eligibility traces (eTraces), silent synaptic processes elicited by activity which upon arrival of a neuromodulator are converted into a lasting change in synaptic strength. Previously we demonstrated in visual cortical slices the Hebbian induction of eTraces and their conversion into LTP and LTD by the retroactive action of norepinephrine and serotonin Here we show in vivo in mouse V1 that the induction of eTraces and their conversion to LTP/D by norepinephrine and serotonin respectively potentiates and depresses visual responses. We also show that the integrity of this process is crucial for ocular dominance plasticity, a canonical model of experience-dependent plasticity.

Suggested Citation

  • Su Z. Hong & Lukas Mesik & Cooper D. Grossman & Jeremiah Y. Cohen & Boram Lee & Daniel Severin & Hey-Kyoung Lee & Johannes W. Hell & Alfredo Kirkwood, 2022. "Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30827-1
    DOI: 10.1038/s41467-022-30827-1
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    References listed on IDEAS

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    1. D. E. Shulz & R. Sosnik & V. Ego & S. Haidarliu & E. Ahissar, 2000. "A neuronal analogue of state-dependent learning," Nature, Nature, vol. 403(6769), pages 549-553, February.
    2. Simon D. Fisher & Paul B. Robertson & Melony J. Black & Peter Redgrave & Mark A. Sagar & Wickliffe C. Abraham & John N.J. Reynolds, 2017. "Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    3. Stijn Cassenaer & Gilles Laurent, 2012. "Conditional modulation of spike-timing-dependent plasticity for olfactory learning," Nature, Nature, vol. 482(7383), pages 47-52, February.
    4. Brittany C. Clawson & Emily J. Pickup & Amy Ensing & Laura Geneseo & James Shaver & John Gonzalez-Amoretti & Meiling Zhao & A. Kane York & Femke Roig Kuhn & Kevin Swift & Jessy D. Martinez & Lijing Wa, 2021. "Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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