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Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer

Author

Listed:
  • R. C. Coombes

    (Imperial College London)

  • P. D. Badman

    (Imperial College London)

  • J. P. Lozano-Kuehne

    (Imperial College London)

  • X. Liu

    (Imperial College London)

  • I. R. Macpherson

    (Beatson West of Scotland Cancer Centre)

  • I. Zubairi

    (Beatson West of Scotland Cancer Centre)

  • R. D. Baird

    (Cancer Research UK Cambridge Centre)

  • N. Rosenfeld

    (Cancer Research UK Cambridge Centre)

  • J. Garcia-Corbacho

    (Cancer Research UK Cambridge Centre)

  • N. Cresti

    (Freeman Hospital)

  • R. Plummer

    (Freeman Hospital)

  • A. Armstrong

    (Christie Hospital)

  • R. Allerton

    (Russell’s Hall Hospital)

  • D. Landers

    (Astrazeneca)

  • H. Nicholas

    (Imperial College London)

  • L. McLellan

    (Cancer Research UK)

  • A. Lim

    (Imperial College London)

  • F. Mouliere

    (Cancer Research UK Cambridge Centre
    Vrije Universiteit Amsterdam, Department of Pathology, Cancer Centre Amsterdam)

  • O. E. Pardo

    (Imperial College London)

  • V. Ferguson

    (Imperial College London)

  • M. J. Seckl

    (Imperial College London)

Abstract

We conducted a phase IIa, multi-centre, open label, single arm study (RADICAL; NCT01791985) of AZD4547 (a potent and selective inhibitor of Fibroblast Growth Factor Receptor (FGFR)-1, 2 and 3 receptor tyrosine kinases) administered with anastrozole or letrozole in estrogen receptor positive metastatic breast cancer patients who had become resistant to aromatase inhibitors. After a safety run-in study to assess safety and tolerability, we recruited 52 patients. The primary endpoint was change in tumour size at 12 weeks, and secondary endpoints were to assess response at 6 weeks, 20 weeks and every 8 weeks thereafter and tolerability of the combined treatment. Two partial responses (PR) and 19 stable disease (SD) patients were observed at the 12-week time point. At 28 weeks, according to centrally reviewed Response Evaluation Criteria in Solid Tumours (RECIST) criteria, five PR and 8 SD patients were observed in 50 assessable cases. Overall, objective response rate (5 PR) was of 10%, meeting the pre-specified endpoint. Fourteen patients discontinued due to adverse events. Eleven patients had retinal pigment epithelial detachments which was asymptomatic and reversible in all but one patient. Exploratory ribonucleic acid sequencing (RNA-Seq) analysis was done on patients’ samples: 6 differentially-expressed-genes could distinguish those who benefited from the addition of AZD4547.

Suggested Citation

  • R. C. Coombes & P. D. Badman & J. P. Lozano-Kuehne & X. Liu & I. R. Macpherson & I. Zubairi & R. D. Baird & N. Rosenfeld & J. Garcia-Corbacho & N. Cresti & R. Plummer & A. Armstrong & R. Allerton & D., 2022. "Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30666-0
    DOI: 10.1038/s41467-022-30666-0
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    References listed on IDEAS

    as
    1. Luigi Formisano & Yao Lu & Alberto Servetto & Ariella B. Hanker & Valerie M. Jansen & Joshua A. Bauer & Dhivya R. Sudhan & Angel L. Guerrero-Zotano & Sarah Croessmann & Yan Guo & Paula Gonzalez Ericss, 2019. "Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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