IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30617-9.html
   My bibliography  Save this article

Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination

Author

Listed:
  • Mladen Jergović

    (University of Arizona College of Medicine
    University of Arizona Center on Aging, University of Arizona, College of Medicine)

  • Jennifer L. Uhrlaub

    (University of Arizona College of Medicine
    University of Arizona Center on Aging, University of Arizona, College of Medicine)

  • Makiko Watanabe

    (University of Arizona College of Medicine
    University of Arizona Center on Aging, University of Arizona, College of Medicine)

  • Christine M. Bradshaw

    (University of Arizona College of Medicine
    University of Arizona Center on Aging, University of Arizona, College of Medicine)

  • Lisa M. White

    (University of Arizona)

  • Bonnie J. LaFleur

    (University of Arizona)

  • Taylor Edwards

    (University of Arizona)

  • Ryan Sprissler

    (University of Arizona
    University of Arizona)

  • Michael Worobey

    (University of Arizona)

  • Deepta Bhattacharya

    (University of Arizona College of Medicine
    University of Arizona)

  • Janko Nikolich-Žugich

    (University of Arizona College of Medicine
    University of Arizona Center on Aging, University of Arizona, College of Medicine
    University of Arizona)

Abstract

Aging is associated with a reduced magnitude of primary immune responses to vaccination. mRNA-based SARS-CoV-2 vaccines have shown efficacy in older adults but virus variant escape is still unclear. Here we analyze humoral and cellular immunity against an early-pandemic viral isolate and compare that to the P.1 (Gamma) and B.1.617.2 (Delta) variants in two cohorts ( 55 age) of mRNA vaccine recipients. We further measure neutralizing antibody titers for B.1.617.1 (Kappa) and B.1.595, with the latter SARS-CoV-2 isolate bearing the spike mutation E484Q. Robust humoral immunity is measured following second vaccination, and older vaccinees manifest cellular immunity comparable to the adult group against early-pandemic SARS-CoV-2 and more recent variants. More specifically, the older cohort has lower neutralizing capacity at 7-14 days following the second dose but equilibrates with the younger cohort after 2-3 months. While long-term vaccination responses remain to be determined, our results implicate vaccine-induced protection in older adults against SARS-CoV-2 variants and inform thinking about boost vaccination.

Suggested Citation

  • Mladen Jergović & Jennifer L. Uhrlaub & Makiko Watanabe & Christine M. Bradshaw & Lisa M. White & Bonnie J. LaFleur & Taylor Edwards & Ryan Sprissler & Michael Worobey & Deepta Bhattacharya & Janko Ni, 2022. "Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30617-9
    DOI: 10.1038/s41467-022-30617-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30617-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30617-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Daan K. J. Pieren & Sebastián G. Kuguel & Joel Rosado & Alba G. Robles & Joan Rey-Cano & Cristina Mancebo & Juliana Esperalba & Vicenç Falcó & María J. Buzón & Meritxell Genescà, 2023. "Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30617-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.