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Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021

Author

Listed:
  • Collins M. Morang’a

    (University of Ghana
    University of Ghana)

  • Joyce M. Ngoi

    (University of Ghana
    University of Ghana)

  • Jones Gyamfi

    (University of Health and Allied Sciences COVID-19 Testing and Research Centre)

  • Dominic S. Y. Amuzu

    (University of Ghana
    University of Ghana)

  • Benjamin D. Nuertey

    (Tamale Teaching Hospital Intensive Care Unit, Ghana Health Service)

  • Philip M. Soglo

    (University of Ghana
    University of Ghana)

  • Vincent Appiah

    (University of Ghana
    University of Ghana)

  • Ivy A. Asante

    (University of Ghana, Legon)

  • Paul Owusu-Oduro

    (LEDing Medical Laboratory)

  • Samuel Armoo

    (Biomedical and Public Health Research Unit, Council for Scientific and Industrial Research)

  • Dennis Adu-Gyasi

    (Kintampo Health Research Centre, Research and Development Division, Ghana Health Service)

  • Nicholas Amoako

    (University of Ghana
    Kintampo Health Research Centre, Research and Development Division, Ghana Health Service)

  • Joseph Oliver-Commey

    (Ghana Infectious Disease Centre)

  • Michael Owusu

    (Kwame Nkrumah University of Science and Technology)

  • Augustina Sylverken

    (Kwame Nkrumah University of Science and Technology)

  • Edward D. Fenteng

    (Veterinary Services Directorate)

  • Violette V. M’cormack

    (University of Ghana
    University of Ghana)

  • Frederick Tei-Maya

    (University of Ghana
    University of Ghana)

  • Evelyn B. Quansah

    (University of Ghana
    University of Ghana)

  • Reuben Ayivor-Djanie

    (University of Health and Allied Sciences COVID-19 Testing and Research Centre)

  • Enock K. Amoako

    (University of Ghana
    University of Ghana)

  • Isaac T. Ogbe

    (University of Ghana
    University of Ghana)

  • Bright K. Yemi

    (University of Ghana
    University of Ghana)

  • Israel Osei-Wusu

    (University of Ghana
    University of Ghana)

  • Deborah N. A. Mettle

    (University of Ghana
    University of Ghana)

  • Samirah Saiid

    (University of Ghana
    University of Ghana)

  • Kesego Tapela

    (University of Ghana
    University of Ghana)

  • Francis Dzabeng

    (University of Ghana
    University of Ghana)

  • Vanessa Magnussen

    (University of Ghana
    University of Ghana
    University of Ghana, Legon)

  • Jerry Quaye

    (University of Ghana
    University of Ghana)

  • Precious C. Opurum

    (University of Ghana
    University of Ghana)

  • Rosina A. Carr

    (University of Health and Allied Sciences COVID-19 Testing and Research Centre)

  • Patrick T. Ababio

    (Veterinary Services Directorate)

  • Abdul-Karim Abass

    (Tamale Public Health and Reference Laboratory, Ghana Health Service)

  • Samuel K. Akoriyea

    (Institutional Care Division (ICD), Ghana Health Service)

  • Emmanuella Amoako

    (Cape Coast Teaching Hospital, Ghana Health Service)

  • Frederick Kumi-Ansah

    (Cape Coast Teaching Hospital, Ghana Health Service)

  • Oliver D. Boakye

    (Ghana Health Service)

  • Dam K. Mibut

    (Tamale Teaching Hospital Intensive Care Unit, Ghana Health Service)

  • Theophilus Odoom

    (Ghana Health Service)

  • Lawrence Ofori-Boadu

    (Ghana Health Service)

  • Emmanuel Allegye-Cudjoe

    (Pong-Tamale Central Veterinary Laboratory, National Veterinary Services Directorate)

  • Sylvester Dassah

    (Navrongo Health Research Centre, Research and Development Division, Ghana Health Service)

  • Victor Asoala

    (Navrongo Health Research Centre, Research and Development Division, Ghana Health Service)

  • Kwaku P. Asante

    (Kintampo Health Research Centre, Research and Development Division, Ghana Health Service)

  • Richard O. Phillips

    (Kwame Nkrumah University of Science and Technology)

  • Mike Y. Osei-Atweneboana

    (Biomedical and Public Health Research Unit, Council for Scientific and Industrial Research)

  • John O. Gyapong

    (University of Health and Allied Sciences COVID-19 Testing and Research Centre)

  • Patrick Kuma-Aboagye

    (Ghana Health Service)

  • William K. Ampofo

    (University of Ghana, Legon)

  • Kwabena O. Duedu

    (University of Health and Allied Sciences COVID-19 Testing and Research Centre)

  • Nicaise T. Ndam

    (Institut de Recherche pour le Développement)

  • Yaw Bediako

    (University of Ghana
    University of Ghana
    Yemaachi Biotechnology)

  • Peter K. Quashie

    (University of Ghana
    University of Ghana)

  • Lucas N. Amenga-Etego

    (University of Ghana
    University of Ghana)

  • Gordon A. Awandare

    (University of Ghana
    University of Ghana)

Abstract

The COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineage, but the second wave was overwhelmingly driven by the Alpha variant. Subsequently, an unheralded variant under monitoring, B.1.1.318, dominated transmission from April to June 2021 before being displaced by Delta variants, which were introduced into community transmission in May 2021. Mutational analysis indicated that variants that took hold in Ghana harboured transmission enhancing and immune escape spike substitutions. The observed rapid viral evolution demonstrates the potential for emergence of novel variants with greater mutational fitness as observed in other parts of the world.

Suggested Citation

  • Collins M. Morang’a & Joyce M. Ngoi & Jones Gyamfi & Dominic S. Y. Amuzu & Benjamin D. Nuertey & Philip M. Soglo & Vincent Appiah & Ivy A. Asante & Paul Owusu-Oduro & Samuel Armoo & Dennis Adu-Gyasi &, 2022. "Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30219-5
    DOI: 10.1038/s41467-022-30219-5
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    References listed on IDEAS

    as
    1. Frederik Plesner Lyngse & Kåre Mølbak & Robert Leo Skov & Lasse Engbo Christiansen & Laust Hvas Mortensen & Mads Albertsen & Camilla Holten Møller & Tyra Grove Krause & Morten Rasmussen & Thomas Yssin, 2021. "Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
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