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Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Author

Listed:
  • Frederik Plesner Lyngse

    (University of Copenhagen
    Danish Ministry of Health
    Statens Serum Institut)

  • Kåre Mølbak

    (Statens Serum Institut
    University of Copenhagen)

  • Robert Leo Skov

    (Statens Serum Institut)

  • Lasse Engbo Christiansen

    (DTU Compute)

  • Laust Hvas Mortensen

    (Statistics Denmark
    University of Copenhagen)

  • Mads Albertsen

    (Aalborg University)

  • Camilla Holten Møller

    (Statens Serum Institut)

  • Tyra Grove Krause

    (Statens Serum Institut)

  • Morten Rasmussen

    (Statens Serum Institut)

  • Thomas Yssing Michaelsen

    (Aalborg University)

  • Marianne Voldstedlund

    (Statens Serum Institut)

  • Jannik Fonager

    (Statens Serum Institut)

  • Nina Steenhard

    (Statens Serum Institut)

  • Carsten Thure Kirkeby

    (University of Copenhagen)

Abstract

New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5–1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

Suggested Citation

  • Frederik Plesner Lyngse & Kåre Mølbak & Robert Leo Skov & Lasse Engbo Christiansen & Laust Hvas Mortensen & Mads Albertsen & Camilla Holten Møller & Tyra Grove Krause & Morten Rasmussen & Thomas Yssin, 2021. "Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27202-x
    DOI: 10.1038/s41467-021-27202-x
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    1. Elham Khatamzas & Markus H. Antwerpen & Alexandra Rehn & Alexander Graf & Johannes Christian Hellmuth & Alexandra Hollaus & Anne-Wiebe Mohr & Erik Gaitzsch & Tobias Weiglein & Enrico Georgi & Clemens , 2022. "Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Collins M. Morang’a & Joyce M. Ngoi & Jones Gyamfi & Dominic S. Y. Amuzu & Benjamin D. Nuertey & Philip M. Soglo & Vincent Appiah & Ivy A. Asante & Paul Owusu-Oduro & Samuel Armoo & Dennis Adu-Gyasi &, 2022. "Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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