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Cooperative catalysis by a single-atom enzyme-metal complex

Author

Listed:
  • Xiaoyang Li

    (Tsinghua University
    Nanchang University)

  • Yufei Cao

    (Tsinghua University)

  • Kai Luo

    (Fudan University)

  • Lin Zhang

    (Tianjin University)

  • Yunxiu Bai

    (Tsinghua University)

  • Jiarong Xiong

    (Tsinghua University)

  • Richard N. Zare

    (Fudan University)

  • Jun Ge

    (Tsinghua University
    Tsinghua Shenzhen International Graduate School)

Abstract

Anchoring single metal atoms on enzymes has great potential to generate hybrid catalysts with high activity and selectivity for reactions that cannot be driven by traditional metal catalysts. Herein, we develop a photochemical method to construct a stable single-atom enzyme-metal complex by binding single metal atoms to the carbon radicals generated on an enzyme-polymer conjugate. The metal mass loading of Pd-anchored enzyme is up to 4.0% while maintaining the atomic dispersion of Pd. The cooperative catalysis between lipase-active site and single Pd atom accelerates alkyl-alkyl cross-coupling reaction between 1-bromohexane and B-n-hexyl-9-BBN with high efficiency (TOF is 540 h−1), exceeding that of the traditional catalyst Pd(OAc)2 by a factor of 300 under ambient conditions.

Suggested Citation

  • Xiaoyang Li & Yufei Cao & Kai Luo & Lin Zhang & Yunxiu Bai & Jiarong Xiong & Richard N. Zare & Jun Ge, 2022. "Cooperative catalysis by a single-atom enzyme-metal complex," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29900-6
    DOI: 10.1038/s41467-022-29900-6
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    References listed on IDEAS

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    1. Zhaobin Wang & Haolin Yin & Gregory C. Fu, 2018. "Catalytic enantioconvergent coupling of secondary and tertiary electrophiles with olefins," Nature, Nature, vol. 563(7731), pages 379-383, November.
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    1. Qiang Chen & Ge Qu & Xu Li & Mingjian Feng & Fan Yang & Yanjie Li & Jincheng Li & Feifei Tong & Shiyi Song & Yujun Wang & Zhoutong Sun & Guangsheng Luo, 2023. "Active and stable alcohol dehydrogenase-assembled hydrogels via synergistic bridging of triazoles and metal ions," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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