IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-29765-9.html
   My bibliography  Save this article

Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish

Author

Listed:
  • Caroline L. Wee

    (Harvard University
    Program in Neuroscience, Department of Neurobiology, Harvard Medical School
    Institute of Molecular and Cell Biology)

  • Erin Song

    (Harvard University)

  • Maxim Nikitchenko

    (Harvard University
    Duke University)

  • Kristian J. Herrera

    (Harvard University)

  • Sandy Wong

    (Harvard University)

  • Florian Engert

    (Harvard University)

  • Samuel Kunes

    (Harvard University)

Abstract

Animal brains have evolved to encode social stimuli and transform these representations into advantageous behavioral responses. The commonalities and differences of these representations across species are not well-understood. Here, we show that social isolation activates an oxytocinergic (OXT), nociceptive circuit in the larval zebrafish hypothalamus and that chemical cues released from conspecific animals are potent modulators of this circuit’s activity. We delineate an olfactory to subpallial pathway that transmits chemical social cues to OXT circuitry, where they are transformed into diverse outputs simultaneously regulating avoidance and feeding behaviors. Our data allow us to propose a model through which social stimuli are integrated within a fundamental neural circuit to mediate diverse adaptive behaviours.

Suggested Citation

  • Caroline L. Wee & Erin Song & Maxim Nikitchenko & Kristian J. Herrera & Sandy Wong & Florian Engert & Samuel Kunes, 2022. "Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29765-9
    DOI: 10.1038/s41467-022-29765-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-29765-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-29765-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Roy Harpaz & Minh Nguyet Nguyen & Armin Bahl & Florian Engert, 2021. "Precise visuomotor transformations underlying collective behavior in larval zebrafish," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Lukas Anneser & Ivan C. Alcantara & Anja Gemmer & Kristina Mirkes & Soojin Ryu & Erin M. Schuman, 2020. "The neuropeptide Pth2 dynamically senses others via mechanosensation," Nature, Nature, vol. 588(7839), pages 653-657, December.
    3. Constantina Theofanopoulou & Gregory Gedman & James A. Cahill & Cedric Boeckx & Erich D. Jarvis, 2021. "Universal nomenclature for oxytocin–vasotocin ligand and receptor families," Nature, Nature, vol. 592(7856), pages 747-755, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Roy Harpaz & Minh Nguyet Nguyen & Armin Bahl & Florian Engert, 2021. "Precise visuomotor transformations underlying collective behavior in larval zebrafish," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Dániel L. Barabási & Gregor F. P. Schuhknecht & Florian Engert, 2024. "Functional neuronal circuits emerge in the absence of developmental activity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Shachar Sherman & Irene Arnold-Ammer & Martin W. Schneider & Koichi Kawakami & Herwig Baier, 2023. "Retina-derived signals control pace of neurogenesis in visual brain areas but not circuit assembly," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Zhicheng Zheng & Yuan Tao & Yalun Xiang & Xiaokang Lei & Xingguang Peng, 2024. "Body orientation change of neighbors leads to scale-free correlation in collective motion," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29765-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.