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Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response

Author

Listed:
  • Denise Chan

    (Imperial College London)

  • Phillip R. Bennett

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London)

  • Yun S. Lee

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London)

  • Samit Kundu

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London)

  • T. G. Teoh

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London
    Imperial College Healthcare NHS Trust)

  • Malko Adan

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London)

  • Saqa Ahmed

    (Imperial College London)

  • Richard G. Brown

    (Imperial College London)

  • Anna L. David

    (University College London)

  • Holly V. Lewis

    (Imperial College London)

  • Belen Gimeno-Molina

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London)

  • Jane E. Norman

    (University of Edinburgh Usher Institute
    University of Bristol)

  • Sarah J. Stock

    (University of Edinburgh Usher Institute)

  • Vasso Terzidou

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London
    Imperial College Healthcare NHS Trust)

  • Pascale Kropf

    (March of Dimes Prematurity Research Center at Imperial College London
    Imperial College London)

  • Marina Botto

    (March of Dimes Prematurity Research Center at Imperial College London
    Imperial College London)

  • David A. MacIntyre

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London)

  • Lynne Sykes

    (Imperial College London
    March of Dimes Prematurity Research Center at Imperial College London
    Imperial College Healthcare NHS Trust)

Abstract

There has been a surge in studies implicating a role of vaginal microbiota in spontaneous preterm birth (sPTB), but most are associative without mechanistic insight. Here we show a comprehensive approach to understand the causative factors of preterm birth, based on the integration of longitudinal vaginal microbiota and cervicovaginal fluid (CVF) immunophenotype data collected from 133 women at high-risk of sPTB. We show that vaginal depletion of Lactobacillus species and high bacterial diversity leads to increased mannose binding lectin (MBL), IgM, IgG, C3b, C5, IL-8, IL-6 and IL-1β and to increased risk of sPTB. Cervical shortening, which often precedes preterm birth, is associated with Lactobacillus iners and elevated levels of IgM, C3b, C5, C5a and IL-6. These data demonstrate a role for the complement system in microbial-driven sPTB and provide a scientific rationale for the development of live biotherapeutics and complement therapeutics to prevent sPTB.

Suggested Citation

  • Denise Chan & Phillip R. Bennett & Yun S. Lee & Samit Kundu & T. G. Teoh & Malko Adan & Saqa Ahmed & Richard G. Brown & Anna L. David & Holly V. Lewis & Belen Gimeno-Molina & Jane E. Norman & Sarah J., 2022. "Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28620-1
    DOI: 10.1038/s41467-022-28620-1
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    References listed on IDEAS

    as
    1. Michal A. Elovitz & Pawel Gajer & Valerie Riis & Amy G. Brown & Michael S. Humphrys & Johanna B. Holm & Jacques Ravel, 2019. "Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
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