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Cost-effectiveness of sleeping sickness elimination campaigns in five settings of the Democratic Republic of Congo

Author

Listed:
  • Marina Antillon

    (Swiss Tropical and Public Health Institute
    University of Basel)

  • Ching-I Huang

    (University of Warwick
    University of Warwick)

  • Ronald E. Crump

    (University of Warwick
    University of Warwick)

  • Paul E. Brown

    (University of Warwick
    University of Warwick)

  • Rian Snijders

    (Swiss Tropical and Public Health Institute
    University of Basel
    Institute of Tropical Medicine)

  • Erick Mwamba Miaka

    (Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA))

  • Matt J. Keeling

    (University of Warwick
    University of Warwick
    University of Warwick)

  • Kat S. Rock

    (University of Warwick
    University of Warwick)

  • Fabrizio Tediosi

    (Swiss Tropical and Public Health Institute
    University of Basel)

Abstract

Gambiense human African trypanosomiasis (gHAT) is marked for elimination of transmission by 2030, but the disease persists in several low-income countries. We couple transmission and health outcomes models to examine the cost-effectiveness of four gHAT elimination strategies in five settings – spanning low- to high-risk – of the Democratic Republic of Congo. Alongside passive screening in fixed health facilities, the strategies include active screening at average or intensified coverage levels, alone or with vector control with a scale-back algorithm when no cases are reported for three consecutive years. In high or moderate-risk settings, costs of gHAT strategies are primarily driven by active screening and, if used, vector control. Due to the cessation of active screening and vector control, most investments (75-80%) are made by 2030 and vector control might be cost-saving while ensuring elimination of transmission. In low-risk settings, costs are driven by passive screening, and minimum-cost strategies consisting of active screening and passive screening lead to elimination of transmission by 2030 with high probability.

Suggested Citation

  • Marina Antillon & Ching-I Huang & Ronald E. Crump & Paul E. Brown & Rian Snijders & Erick Mwamba Miaka & Matt J. Keeling & Kat S. Rock & Fabrizio Tediosi, 2022. "Cost-effectiveness of sleeping sickness elimination campaigns in five settings of the Democratic Republic of Congo," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28598-w
    DOI: 10.1038/s41467-022-28598-w
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    References listed on IDEAS

    as
    1. Rian Snijders & Alain Fukinsia & Yves Claeys & Alain Mpanya & Epco Hasker & Filip Meheus & Erick Miaka & Marleen Boelaert, 2020. "Cost of a new method of active screening for human African trypanosomiasis in the Democratic Republic of the Congo," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(12), pages 1-13, December.
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