Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates
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DOI: 10.1038/s41467-022-28396-4
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- Frank J. Poelwijk & Michael Socolich & Rama Ranganathan, 2019. "Learning the pattern of epistasis linking genotype and phenotype in a protein," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
- Conor J. McClune & Aurora Alvarez-Buylla & Christopher A. Voigt & Michael T. Laub, 2019. "Engineering orthogonal signalling pathways reveals the sparse occupancy of sequence space," Nature, Nature, vol. 574(7780), pages 702-706, October.
- Javin P. Oza & Hans R. Aerni & Natasha L. Pirman & Karl W. Barber & Charlotte M. ter Haar & Svetlana Rogulina & Matthew B. Amrofell & Farren J. Isaacs & Jesse Rinehart & Michael C. Jewett, 2015. "Robust production of recombinant phosphoproteins using cell-free protein synthesis," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
- Stephane Emond & Maya Petek & Emily J. Kay & Brennen Heames & Sean R. A. Devenish & Nobuhiko Tokuriki & Florian Hollfelder, 2020. "Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
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- Philipp Knyphausen & Mariana Rangel Pereira & Paul Brear & Marko Hyvönen & Lutz Jermutus & Florian Hollfelder, 2023. "Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
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