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NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis

Author

Listed:
  • Tomasz Bieluszewski

    (Adam Mickiewicz University)

  • Weronika Sura

    (Adam Mickiewicz University)

  • Wojciech Dziegielewski

    (Adam Mickiewicz University)

  • Anna Bieluszewska

    (Adam Mickiewicz University)

  • Catherine Lachance

    (CHU de Québec-UL Research Center-Oncology Division)

  • Michał Kabza

    (Adam Mickiewicz University)

  • Maja Szymanska-Lejman

    (Adam Mickiewicz University)

  • Mateusz Abram

    (Adam Mickiewicz University)

  • Piotr Wlodzimierz

    (Adam Mickiewicz University)

  • Nancy Winne

    (VIB-UGent Center for Plant Systems Biology)

  • Geert Jaeger

    (VIB-UGent Center for Plant Systems Biology)

  • Jan Sadowski

    (Adam Mickiewicz University)

  • Jacques Côté

    (CHU de Québec-UL Research Center-Oncology Division)

  • Piotr A. Ziolkowski

    (Adam Mickiewicz University)

Abstract

Nucleosomal acetyltransferase of H4 (NuA4) is an essential transcriptional coactivator in eukaryotes, but remains poorly characterized in plants. Here, we describe Arabidopsis homologs of the NuA4 scaffold proteins Enhancer of Polycomb-Like 1 (AtEPL1) and Esa1-Associated Factor 1 (AtEAF1). Loss of AtEAF1 results in inhibition of growth and chloroplast development. These effects are stronger in the Atepl1 mutant and are further enhanced by loss of Golden2-Like (GLK) transcription factors, suggesting that NuA4 activates nuclear plastid genes alongside GLK. We demonstrate that AtEPL1 is necessary for nucleosomal acetylation of histones H4 and H2A.Z by NuA4 in vitro. These chromatin marks are diminished genome-wide in Atepl1, while another active chromatin mark, H3K9 acetylation (H3K9ac), is locally enhanced. Expression of many chloroplast-related genes depends on NuA4, as they are downregulated with loss of H4ac and H2A.Zac. Finally, we demonstrate that NuA4 promotes H2A.Z deposition and by doing so prevents spurious activation of stress response genes.

Suggested Citation

  • Tomasz Bieluszewski & Weronika Sura & Wojciech Dziegielewski & Anna Bieluszewska & Catherine Lachance & Michał Kabza & Maja Szymanska-Lejman & Mateusz Abram & Piotr Wlodzimierz & Nancy Winne & Geert J, 2022. "NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27882-5
    DOI: 10.1038/s41467-021-27882-5
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    Cited by:

    1. Julia Dluzewska & Wojciech Dziegielewski & Maja Szymanska-Lejman & Monika Gazecka & Ian R. Henderson & James D. Higgins & Piotr A. Ziolkowski, 2023. "MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Maja Szymanska-Lejman & Wojciech Dziegielewski & Julia Dluzewska & Nadia Kbiri & Anna Bieluszewska & R. Scott Poethig & Piotr A. Ziolkowski, 2023. "The effect of DNA polymorphisms and natural variation on crossover hotspot activity in Arabidopsis hybrids," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Ben Liao & You-Huang Xiang & Yan Li & Kai-Yang Yang & Jun-Xiang Shan & Wang-Wei Ye & Nai-Qian Dong & Yi Kan & Yi-Bing Yang & Huai-Yu Zhao & Hong-Xiao Yu & Zi-Qi Lu & Yan Zhao & Qiang Zhao & Dongling G, 2024. "Dysfunction of duplicated pair rice histone acetyltransferases causes segregation distortion and an interspecific reproductive barrier," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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